YS-035 hydrochloride

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Cat.No. 0416 - YS-035 hydrochloride | C21H29NO4.HCl | CAS No. 89805-39-0
Description: Inhibits K+ outward/pacemaker current
Chemical Name: N,N-Bis-(3,4-dimethoxyphenylethyl)-N-methylamine hydrochloride
Datasheet
Citations
Literature

Biological Activity

A Ca2+ blocker that strikingly prolongs cardiac action potentials by inhibiting pacemaker current and K+ outward currents.

Technical Data

M. Wt 395.93
Formula C21H29NO4.HCl
Storage Desiccate at RT
CAS Number 89805-39-0
PubChem ID 56017
InChI Key GYBONEHHSUABAO-UHFFFAOYSA-N
Smiles Cl.COC1=CC=C(CCN(C)CCC2=CC=C(OC)C(OC)=C2)C=C1OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 395.93. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.53 mL 12.63 mL 25.26 mL
5 mM 0.51 mL 2.53 mL 5.05 mL
10 mM 0.25 mL 1.26 mL 2.53 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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Product Datasheets

Certificate of Analysis is currently unavailable
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Safety Datasheet

References

References are publications that support the products' biological activity.

Berger et al (1991) Inhibition of potassium outward currents and pacemaker current in sheep cardiac Purkinje fibres by the verapamil derivative YS-035. Naunyn Schmiedebergs Arch.Pharmacol. 344 653 PMID: 1775198

Deana et al (1984) Properties of a new calcium ion antagonist on cellular uptake and mitochondrial efflux of calcium ions. Biochem.J. 218 899 PMID: 6721841


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Keywords: YS-035 hydrochloride, supplier, inhibitors, inhibits, K+, outward, pacemaker, current, Potassium, Channels, Non-Selective, Non-selective, /, Other, Potassium, Channels, HCN, Channels, Non-selective, /, Other, Potassium, Channels, Tocris Bioscience

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