A Ca2+ blocker that strikingly prolongs cardiac action potentials by inhibiting pacemaker current and K+ outward currents.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 100 mM in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 395.93. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.53 mL||12.63 mL||25.26 mL|
|5 mM||0.51 mL||2.53 mL||5.05 mL|
|10 mM||0.25 mL||1.26 mL||2.53 mL|
|50 mM||0.05 mL||0.25 mL||0.51 mL|
References are publications that support the products' biological activity.
Berger et al (1991) Inhibition of potassium outward currents and pacemaker current in sheep cardiac Purkinje fibres by the verapamil derivative YS-035. Naunyn Schmiedebergs Arch.Pharmacol. 344 653 PMID: 1775198
Deana et al (1984) Properties of a new calcium ion antagonist on cellular uptake and mitochondrial efflux of calcium ions. Biochem.J. 218 899 PMID: 6721841
If you know of a relevant reference for YS-035 hydrochloride, please let us know.
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Keywords: YS-035 hydrochloride, supplier, inhibitors, inhibits, K+, outward, pacemaker, current, Potassium, Channels, Non-Selective, Non-selective, /, Other, Potassium, Channels, HCN, Channels, Non-selective, /, Other, Potassium, Channels, Tocris Bioscience
Citations for YS-035 hydrochloride
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New Product Guide (Spring/Summer 2017)
Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.
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