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A Ca2+ blocker that strikingly prolongs cardiac action potentials by inhibiting pacemaker current and K+ outward currents.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 395.93. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.53 mL||12.63 mL||25.26 mL|
|5 mM||0.51 mL||2.53 mL||5.05 mL|
|10 mM||0.25 mL||1.26 mL||2.53 mL|
|50 mM||0.05 mL||0.25 mL||0.51 mL|
References are publications that support the biological activity of the product.
Berger et al (1991) Inhibition of potassium outward currents and pacemaker current in sheep cardiac Purkinje fibres by the vera. derivative YS-035. Naunyn Schmiedebergs Arch.Pharmacol. 344 653 PMID: 1775198
Deana et al (1984) Properties of a new calcium ion antagonist on cellular uptake and mitochondrial efflux of calcium ions. Biochem.J. 218 899 PMID: 6721841
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Keywords: YS-035 hydrochloride, YS-035 hydrochloride supplier, inhibitors, inhibits, K+, outward, pacemaker, current, Potassium, Channels, Non-Selective, Non-selective, /, Other, HCN, 0416, Tocris Bioscience
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