Yoda 2

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: Piezo1 channel activator
Chemical Name: Potassium 4-(5-((2,6-dichlorobenzyl)thio)-1,3,4-thiadiazol-2-yl)benzoate
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for Yoda 2

Yoda 2 is a selective Piezo1 channel activator (EC50 values are 150 nM and 1.14 μM in mPiezo1 and HUVEC cells respectively). Increases Ca2+ signaling 2.8 fold in hPIEZO-TREx and 1.2 fold in mPIEZO1-TREx, compared to Yoda 1 (Cat. No. 5586). Induces concentration-dependent relaxation of mouse portal vein (EC50 = 1.2 μM). Suitable for use in vivo and in vitro.

Technical Data for Yoda 2

M. Wt 435.38
Formula C16H9Cl2N2O2S2K
Storage Store at -20°C
Purity ≥97% (HPLC)
InChI Key OQEIWUHZUPFUQU-UHFFFAOYSA-M
Smiles O=C([O-])C1=CC=C(C2=NN=C(SCC3=C(Cl)C=CC=C3Cl)S2)C=C1.[K+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Yoda 2

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 43.54 100
DMSO 21.77 50

Preparing Stock Solutions for Yoda 2

The following data is based on the product molecular weight 435.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.3 mL 11.48 mL 22.97 mL
5 mM 0.46 mL 2.3 mL 4.59 mL
10 mM 0.23 mL 1.15 mL 2.3 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for Yoda 2

References are publications that support the biological activity of the product.

Parsonage et al (2023) Improved PIEZO1 agonism through 4-benzoic acid modification of Yoda1. Br.J.Pharmacology 180 2039 PMID: 36457143


If you know of a relevant reference for Yoda 2, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Piezo Channel Activators

Keywords: Yoda 2, Yoda 2 supplier, Yoda2, piezo1, piezo, channel, channels, activator, activators, calcium, signaling, vein, relaxation, in, vivo, vitro, Piezo, Channels, 8051, Tocris Bioscience

Citations for Yoda 2

Citations are publications that use Tocris products.

Currently there are no citations for Yoda 2. Do you know of a great paper that uses Yoda 2 from Tocris? Please let us know.

Reviews for Yoda 2

There are currently no reviews for this product. Be the first to review Yoda 2 and earn rewards!

Have you used Yoda 2?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review