Yoda 2

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Description: Piezo1 channel activator
Chemical Name: Potassium 4-(5-((2,6-dichlorobenzyl)thio)-1,3,4-thiadiazol-2-yl)benzoate
Purity: ≥97% (HPLC)

Biological Activity for Yoda 2

Yoda 2 is a selective Piezo1 channel activator (EC50 values are 150 nM and 1.14 μM in mPiezo1 and HUVEC cells respectively). Increases Ca2+ signaling 2.8 fold in hPIEZO-TREx and 1.2 fold in mPIEZO1-TREx, compared to Yoda 1 (Cat. No. 5586). Induces concentration-dependent relaxation of mouse portal vein (EC50 = 1.2 μM). Suitable for use in vivo and in vitro.

Technical Data for Yoda 2

M. Wt 435.38
Formula C16H9Cl2N2O2S2K
Storage Store at -20°C
Purity ≥97% (HPLC)
Smiles O=C([O-])C1=CC=C(C2=NN=C(SCC3=C(Cl)C=CC=C3Cl)S2)C=C1.[K+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Yoda 2

Solvent Max Conc. mg/mL Max Conc. mM
water 43.54 100
DMSO 21.77 50

Preparing Stock Solutions for Yoda 2

The following data is based on the product molecular weight 435.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.3 mL 11.48 mL 22.97 mL
5 mM 0.46 mL 2.3 mL 4.59 mL
10 mM 0.23 mL 1.15 mL 2.3 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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References for Yoda 2

References are publications that support the biological activity of the product.

Parsonage et al (2023) Improved PIEZO1 agonism through 4-benzoic acid modification of Yoda1. Br.J.Pharmacology 180 2039 PMID: 36457143

If you know of a relevant reference for Yoda 2, please let us know.

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Citations for Yoda 2

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