Yoda 1

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Cat.No. 5586 - Yoda 1 | C13H8Cl2N4S2 | CAS No. 448947-81-7
Description: Piezo1 channel activator
Chemical Name: 2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]pyrazine
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews (1)

Biological Activity

Piezo1 channel activator. Slows the inactivation phase of transient currents, sensitizes Piezo1 to activation by pressure, and partially activates channels in the absence of external pressure, in HEK cells expressing Piezo1 channels.

Compound Libraries

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Technical Data

M. Wt 355.27
Formula C13H8Cl2N4S2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 448947-81-7
PubChem ID 2746822
InChI Key BQNXBSYSQXSXPT-UHFFFAOYSA-N
Smiles ClC1=C(CSC2=NN=C(C3=NC=CN=C3)S2)C(Cl)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 17.76 50

Preparing Stock Solutions

The following data is based on the product molecular weight 355.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.81 mL 14.07 mL 28.15 mL
5 mM 0.56 mL 2.81 mL 5.63 mL
10 mM 0.28 mL 1.41 mL 2.81 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Syeda et al (2015) Chemical activation of the mechanotransduction channel Piezo1. ELife 4 e07369 PMID: 26001275


If you know of a relevant reference for Yoda 1, please let us know.

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Keywords: Yoda 1, Yoda 1 supplier, Yoda1, Piezo1, calcium, channels, activators, sensitizers, sensitizes, Ca2+, currents, mechanotransduction, Other, Calcium, Channels, 5586, Tocris Bioscience

1 Citation for Yoda 1

Citations are publications that use Tocris products. Selected citations for Yoda 1 include:

Dela Paz (2018) Yoda1-induced phosphorylation of Akt and ERK1/2 does not require Piezo1 activation. Biochem Biophys Res Commun 497 220 PMID: 29428723


Do you know of a great paper that uses Yoda 1 from Tocris? Please let us know.

Reviews for Yoda 1

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A potent piezo1 receptor activator
By Hyun Choi on 02/21/2018
Assay Type: Ex Vivo
Species: Rat

We used to stimulate piezo1 receptor at around 1-10microM