Yoda 1

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Cat.No. 5586 - Yoda 1 | C13H8Cl2N4S2 | CAS No. 448947-81-7
Description: Piezo1 channel activator
Chemical Name: 2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]pyrazine
Purity: ≥99% (HPLC)

Biological Activity

Piezo1 channel activator. Slows the inactivation phase of transient currents, sensitizes Piezo1 to activation by pressure, and partially activates channels in the absence of external pressure, in HEK cells expressing Piezo1 channels.

Compound Libraries

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Technical Data

M. Wt 355.27
Formula C13H8Cl2N4S2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 448947-81-7
PubChem ID 2746822
Smiles ClC1=C(CSC2=NN=C(C3=NC=CN=C3)S2)C(Cl)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 17.76 50

Preparing Stock Solutions

The following data is based on the product molecular weight 355.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.81 mL 14.07 mL 28.15 mL
5 mM 0.56 mL 2.81 mL 5.63 mL
10 mM 0.28 mL 1.41 mL 2.81 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Syeda et al (2015) Chemical activation of the mechanotransduction channel Piezo1. ELife 4 e07369 PMID: 26001275

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