YM 976

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Cat.No. 1821 - YM 976 | C17H16ClN3O | CAS No. 191219-80-4
Description: PDE4 inhibitor
Chemical Name: 4-(3-Chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Orally active PDE4 inhibitor (IC50 = 2.2 nM). Low emetogenic activity, suggested to be due to poor brain penetration.

Compound Libraries

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Technical Data

M. Wt 313.79
Formula C17H16ClN3O
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 191219-80-4
PubChem ID 6604918
InChI Key MNHXYNNKDDXKNP-UHFFFAOYSA-N
Smiles CCN1C(=O)N=C(C2=CC=CC(Cl)=C2)C2=C1N=C(CC)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.38 100
ethanol 31.38 100

Preparing Stock Solutions

The following data is based on the product molecular weight 313.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.19 mL 15.93 mL 31.87 mL
5 mM 0.64 mL 3.19 mL 6.37 mL
10 mM 0.32 mL 1.59 mL 3.19 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Aoki et al (2000) A novel phosphodiesterase type 4 inhibitor, YM976 (4-(3-chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one), with little emetogenic activity. J.Pharmacol.Exp.Ther. 295 255 PMID: 10991987

Aoki et al (2001) Studies on mechanisms of low emetogenicity of YM976, a novel phosphodiesterase type 4 inhibitor. J.Pharmacol.Exp.Ther. 298 1142 PMID: 11504812

Moriuchi et al (2003) Relaxant effect of YM976, a novel phosphodiesterase 4 inhibitor, on bovine tracheal smooth muscle. Eur.J.Pharmacol. 470 57 PMID: 12787831


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Keywords: YM 976, supplier, PDE4, inhibitors, inhibits, Phosphodiesterases, YM976, Phosphodiesterases, Phosphodiesterases, Tocris Bioscience

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