YM 90K hydrochloride

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Cat.No. 2701 - YM 90K hydrochloride | C11H7N5O4.HCl | CAS No. 154164-30-4
Description: Selective AMPA antagonist
Chemical Name: 1,4-Dihydro-6-(1H-imidazol-1-yl)-7-nitro-2,3-quinoxalinedione hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective AMPA receptor antagonist (Ki values are 84, 2200 and > 37000 nM for AMPA, kainate and NMDA receptors respectively). Neuroprotective; delays neuronal death in a global ischemia model and cerebral infarction in a focal ischemia model following postischemic administration.

Licensing Information

Sold with the permission of Astellas Pharma Inc.

Technical Data

M. Wt 309.67
Formula C11H7N5O4.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 154164-30-4
PubChem ID 5486547
InChI Key UMLFDVOHVJPDIZ-UHFFFAOYSA-N
Smiles O=C(N2)C(NC1=C2C=C(N3C=NC=C3)C([N+]([O-])=O)=C1)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.1 10 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 309.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.29 mL 161.46 mL 322.92 mL
0.5 mM 6.46 mL 32.29 mL 64.58 mL
1 mM 3.23 mL 16.15 mL 32.29 mL
5 mM 0.65 mL 3.23 mL 6.46 mL

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References

References are publications that support the biological activity of the product.

Ohmori et al (1994) 6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione hydrochloride (YM90K) and related compounds: structure-activity relationships for the AMPA-type non-NMDA receptor. J.Med.Chem. 37 467 PMID: 8120865

Umemura et al (1997) Neuroprotective effect of a novel AMPA receptor antagonist, YM90K, in rat focal cerebral ischaemia. Brain Res. 773 61 PMID: 9409705

Nakano et al (2001) A potent AMPA/kainate receptor antagonist, YM90K, attenuates the loss of N-acetylaspartate in the hippocampal CA1 area after transient unilateral forebrain ischemia in gerbils. Life Sci. 69 1983 PMID: 11589513


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