YM 90709

Discontinued Product

YM 90709 (Cat. No. 1675) has been withdrawn from sale for commercial reasons.
Description: Interleukin-5 receptor antagonist
Chemical Name: 5,6-Dihydro-2,3-dimethoxy-6,6-dimethylbenz[7,8]indolizino[2,3-b]quinoxaline
Purity: ≥99% (HPLC)

Biological Activity for YM 90709

YM 90709 is a novel, selective inhibitor of interleukin-5 (IL-5) (IC50 = 0.45 - 1 mM). Inhibits IL-5-prolonged eosinophil survival and IL-5-induced tyrosine phosphorylation of JAK2 without inhibiting GM-CSF-mediated effects. Inhibits antigen-induced eosinophil and lymphocyte recruitment in rat airways in vivo, without affecting peripheral blood or bone marrow leukocytes.

Licensing Information

Sold with the permission of Astellas Pharma Inc.

Technical Data for YM 90709

M. Wt 359.43
Formula C22H21N3O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 163769-88-8
PubChem ID 1103147
Smiles COC1=CC2=C(C=C1OC)C1=CC3=NC4=CC=CC=C4N=C3N1C(C)(C)C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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Keywords: YM 90709, YM 90709 supplier, Interleukin-5, receptor, inhibitors, inhibits, antagonists, IL, receptors, interleukins, cytokines, YM90709, IL-5, inhibitor, Cytokine, Receptors, 1675, Tocris Bioscience

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