YM 90709

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Cat.No. 1675 - YM 90709 | C22H21N3O2 | CAS No. 163769-88-8
Description: Interleukin-5 receptor antagonist
Chemical Name: 5,6-Dihydro-2,3-dimethoxy-6,6-dimethylbenz[7,8]indolizino[2,3-b]quinoxaline
Purity: ≥99% (HPLC)
Literature (3)

Biological Activity for YM 90709

YM 90709 is a novel, selective inhibitor of interleukin-5 (IL-5) (IC50 = 0.45 - 1 mM). Inhibits IL-5-prolonged eosinophil survival and IL-5-induced tyrosine phosphorylation of JAK2 without inhibiting GM-CSF-mediated effects. Inhibits antigen-induced eosinophil and lymphocyte recruitment in rat airways in vivo, without affecting peripheral blood or bone marrow leukocytes.

Licensing Information

Sold with the permission of Astellas Pharma Inc.

Technical Data for YM 90709

M. Wt 359.43
Formula C22H21N3O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 163769-88-8
PubChem ID 1103147
Smiles COC1=CC2=C(C=C1OC)C1=CC3=NC4=CC=CC=C4N=C3N1C(C)(C)C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for YM 90709

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 8.99 25
DMSO 17.97 50

Preparing Stock Solutions for YM 90709

The following data is based on the product molecular weight 359.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.56 mL 27.82 mL 55.64 mL
2.5 mM 1.11 mL 5.56 mL 11.13 mL
5 mM 0.56 mL 2.78 mL 5.56 mL
25 mM 0.11 mL 0.56 mL 1.11 mL

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References for YM 90709

References are publications that support the biological activity of the product.

Morokata et al (2002) Characterization of YM-90709 as a novel antagonist which inhibits the binding of interleukin-5 to interleukin-5 receptor. Int.Immunopharmacol. 2 1693 PMID: 12469943

Morokata et al (2004) Effect of a novel interleukin-5 receptor antagonist, YM-90709 (2,3-dimethoxy-6,6-dimethyl-5,6-dihydrobenzo[7,8]indolizino[2,3-b]quinoxaline), on antigen-induced airway inflammation in BN rats. Int.Immunopharmacol. 4 873 PMID: 15182727

Morokata et al (2005) Effect of a novel interleukin-5 receptor antagonist, YM-90709, on antigen-induced eosinophil infiltration into the airway of BDF1 mice. Immunol.Lett. 98 161 PMID: 15790522

If you know of a relevant reference for YM 90709, please let us know.

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