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Competitive inhibitor of secretory phospholipase A2 (sPLA2) that exhibits a broad inhibitory profile to several sPLA2s (IC50 values are 0.2, 1, 1, 1 and 3 μM for sPLA2-X, -IIA, -IID, -V and -IIE respectively). Displays minimal activity at sPLA2-IIF and no activity at cytosolic PLA2, cyclooxygenase and lipoxygenase. Ameliorates local inflammatory responses in TPA-induced mouse ear edema.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 730.97. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.37 mL||6.84 mL||13.68 mL|
|5 mM||0.27 mL||1.37 mL||2.74 mL|
|10 mM||0.14 mL||0.68 mL||1.37 mL|
|50 mM||0.03 mL||0.14 mL||0.27 mL|
References are publications that support the biological activity of the product.
Miyake et al (1993) Suppression of inflammatory responses to 12-O-tetradecanoyl-phorbol-13-acetate and carregeenin by YM-26734, a selective inhibitor of extracellular group II phospholipase A2. Br.J.Pharmacol. 110 447 PMID: 8220906
Miyake et al (1994) Exogenous group II phospholipase A2 prostaglandin E2 production in mouse peritoneal macrophages. Eur.J.Pharmacol. 253 155 PMID: 8013541
Hamaguchi et al (2003) Induction of distinct sets of secretory phospholipase A2 in rodents during inflammation. Biochim.Biophys.Acta 1635 37 PMID: 14642775
If you know of a relevant reference for YM 26734, please let us know.
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Keywords: YM 26734, YM 26734 supplier, Secretory, phospholipases, A2, sPLA2, inhibitors, inhibits, Esterases, YM26734, Phospholipases, 2522, Tocris Bioscience
2 Citations for YM 26734
Citations are publications that use Tocris products. Selected citations for YM 26734 include:
Bianca et al (2010) Hydrogen sulphide induces mouse paw oedema through activation of phospholipase A2. Front Mol Neurosci 161 1835 PMID: 20825409
Pernet et al (2014) Pseudomonas aeruginosa eradicates Staphylococcus aureus by manipulating the host immunity. Nat Commun 5 5105 PMID: 25290234
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