YK 3-237

Discontinued Product

YK 3-237 (Cat. No. 5667) has been withdrawn from sale for commercial reasons.
Description: SIRT1 activator
Chemical Name: B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for YK 3-237

YK 3-237 is a SIRT1 activator. Inhibits proliferation of breast cancer cell lines expressing mutant p53. Induces G2/M cell cycle arrest and apoptosis in triple negative breast cancer cells (TNBCs) in vitro.

Technical Data for YK 3-237

M. Wt 372.18
Formula C19H21BO7
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1215281-19-8
PubChem ID 24881094
Smiles O=C(/C=C/C1=CC=C(OC)C(B(O)O)=C1)C2=CC(OC)=C(OC)C(OC)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for YK 3-237

References are publications that support the biological activity of the product.

Yi et al (2013) Targeting mutant p53 by a SIRT1 activator YK-3-237 inhibits the proliferation of triple-negative breast cancer cells. Oncotarget 4 984 PMID: 23846322

Ponnusamy et al (2015) Activation of sirtuin-1 promotes renal fibroblast activation and aggravates renal fibrogenesis. J.Pharmacol.Exp.Ther 354 142 PMID: 26022003

View Related Products by Product Action

View all Class III HDAC (Sirtuin) Activators

Keywords: YK 3-237, YK 3-237 supplier, YK3-237, SIRT1, sirtuins, activators, activates, deacetylases, antiproliferative, Class, III, HDACs, (Sirtuins), 5667, Tocris Bioscience

Citations for YK 3-237

Citations are publications that use Tocris products.

Currently there are no citations for YK 3-237.

Reviews for YK 3-237

There are currently no reviews for this product. Be the first to review YK 3-237 and earn rewards!

Have you used YK 3-237?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Rheumatoid Arthritis Poster

Rheumatoid Arthritis Poster

Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.