YK 3-237

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Cat.No. 5667 - YK 3-237 | C19H21BO7 | CAS No. 1215281-19-8
Description: SIRT1 activator
Chemical Name: B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

SIRT1 activator. Inhibits proliferation of breast cancer cell lines expressing mutant p53. Induces G2/M cell cycle arrest and apoptosis in triple negative breast cancer cells (TNBCs) in vitro.

Technical Data

M. Wt 372.18
Formula C19H21BO7
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1215281-19-8
PubChem ID 24881094
InChI Key AKNGHUAJAODDJA-FNORWQNLSA-N
Smiles O=C(/C=C/C1=CC=C(OC)C(B(O)O)=C1)C2=CC(OC)=C(OC)C(OC)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.22 100
ethanol 37.22 100

Preparing Stock Solutions

The following data is based on the product molecular weight 372.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.69 mL 13.43 mL 26.87 mL
5 mM 0.54 mL 2.69 mL 5.37 mL
10 mM 0.27 mL 1.34 mL 2.69 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Yi et al (2013) Targeting mutant p53 by a SIRT1 activator YK-3-237 inhibits the proliferation of triple-negative breast cancer cells. Oncotarget 4 984 PMID: 23846322

Ponnusamy et al (2015) Activation of sirtuin-1 promotes renal fibroblast activation and aggravates renal fibrogenesis. J.Pharmacol.Exp.Ther 354 142 PMID: 26022003


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Keywords: YK 3-237, YK 3-237 supplier, YK3-237, SIRT1, sirtuins, activators, activates, deacetylases, antiproliferative, Class, III, Histone, Deacetylases, (Sirtuins), 5667, Tocris Bioscience

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