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Biological Activity for YK 3-237
YK 3-237 is a SIRT1 activator. Inhibits proliferation of breast cancer cell lines expressing mutant p53. Induces G2/M cell cycle arrest and apoptosis in triple negative breast cancer cells (TNBCs) in vitro.
Technical Data for YK 3-237
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for YK 3-237
References are publications that support the biological activity of the product.
Yi et al (2013) Targeting mutant p53 by a SIRT1 activator YK-3-237 inhibits the proliferation of triple-negative breast cancer cells. Oncotarget 4 984 PMID: 23846322
Ponnusamy et al (2015) Activation of sirtuin-1 promotes renal fibroblast activation and aggravates renal fibrogenesis. J.Pharmacol.Exp.Ther 354 142 PMID: 26022003
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Keywords: YK 3-237, YK 3-237 supplier, YK3-237, SIRT1, sirtuins, activators, activates, deacetylases, antiproliferative, Class, III, HDACs, (Sirtuins), 5667, Tocris Bioscience
Citations for YK 3-237
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Currently there are no citations for YK 3-237.
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