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Y-25130 hydrochloride

Cat. No. 0380 2 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective 5-HT3 antagonist
Chemical Name: N-(1-Azabicyclo[2.2.2]oct-3-yl)-6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Y-25130 hydrochloride

Y-25130 hydrochloride is a selective and potent 5-HT3 antagonist (Ki = 2.9 nM).

Technical Data for Y-25130 hydrochloride

M. Wt 386.28
Formula C17H20ClN3O3.HCl
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 123040-16-4
PubChem ID 115000
InChI Key DBMKBKPJYAHLQP-UHFFFAOYSA-N
Smiles Cl.CN1C(=O)COC2=C(C=C(Cl)C=C12)C(=O)NC1CN2CCC1CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Y-25130 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 100
DMSO 3.86 10

Preparing Stock Solutions for Y-25130 hydrochloride

The following data is based on the product molecular weight 386.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.59 mL 12.94 mL 25.89 mL
5 mM 0.52 mL 2.59 mL 5.18 mL
10 mM 0.26 mL 1.29 mL 2.59 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Product Datasheets for Y-25130 hydrochloride

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for Y-25130 hydrochloride

References are publications that support the biological activity of the product.

Fukuda et al (1991) The antiemetic profile of Y-25130, a new selective 5-HT3 receptor antagonist. Eur.J.Pharmacol. 196 299 PMID: 1654255

Haga et al (1993) The effects of orally administered Y-25130, a selective serotonin3 receptor antagonist on chemotherapeutic agent-induced emesis. Jpn.J.Pharmacol. 63 377 PMID: 8107329

Sato et al (1992) Antagonistic activity of Y-25130 on 5-HT3 receptors. Jpn.J.Pharmacol. 59 443 PMID: 1331590

If you know of a relevant reference for Y-25130 hydrochloride, please let us know.

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2 Citations for Y-25130 hydrochloride

Citations are publications that use Tocris products. Selected citations for Y-25130 hydrochloride include:

Sándor et al (2018) Evidence Supports Tradition: The in Vitro Effects of Roman Chamomile on Smooth Muscles. Front Pharmacol 9 323 PMID: 29681854

Xiao et al (2008) Release of glutamate and CGRP from trigeminal ganglion neurons: Role of calcium channels and 5-HT1 receptor signaling. Proc Natl Acad Sci U S A 4 12 PMID: 18416824

Do you know of a great paper that uses Y-25130 hydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Ion Channel Product Listing

Ion Channel Product Listing

A collection of around 500 products for ion channel research, the listing includes research tools for the study of:

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5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.