Y-25130 hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 0380 - Y-25130 hydrochloride | C17H20ClN3O3.HCl | CAS No. 123040-16-4
Description: Potent, selective 5-HT3 antagonist
Chemical Name: N-(1-Azabicyclo[2.2.2]oct-3-yl)-6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

A selective and potent 5-HT3 antagonist (Ki = 2.9 nM).

Technical Data

M. Wt 386.28
Formula C17H20ClN3O3.HCl
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 123040-16-4
PubChem ID 115000
InChI Key DBMKBKPJYAHLQP-UHFFFAOYSA-N
Smiles Cl.CN1C(=O)COC2=C(C=C(Cl)C=C12)C(=O)NC1CN2CCC1CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.86 10
water 100

Preparing Stock Solutions

The following data is based on the product molecular weight 386.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.59 mL 12.94 mL 25.89 mL
5 mM 0.52 mL 2.59 mL 5.18 mL
10 mM 0.26 mL 1.29 mL 2.59 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Fukuda et al (1991) The antiemetic profile of Y-25130, a new selective 5-HT3 receptor antagonist. Eur.J.Pharmacol. 196 299 PMID: 1654255

Haga et al (1993) The effects of orally administered Y-25130, a selective serotonin3 receptor antagonist on chemotherapeutic agent-induced emesis. Jpn.J.Pharmacol. 63 377 PMID: 8107329

Sato et al (1992) Antagonistic activity of Y-25130 on 5-HT3 receptors. Jpn.J.Pharmacol. 59 443 PMID: 1331590


If you know of a relevant reference for Y-25130 hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all 5-HT3 Receptor Antagonists

Keywords: Potent selective 5-HT3 antagonists Serotonin Receptors 5-HT3 Receptors

1 Citation for Y-25130 hydrochloride

Citations are publications that use Tocris products. Selected citations for Y-25130 hydrochloride include:

Xiao et al (2008) Release of glutamate and CGRP from trigeminal ganglion neurons: Role of calcium channels and 5-HT1 receptor signaling. Proc Natl Acad Sci U S A 4 12 PMID: 18416824


Do you know of a great paper that uses Y-25130 hydrochloride from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Pathways for Y-25130 hydrochloride

Protocols

TODO: Add Protocols