Y 11

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Cat.No. 4498 - Y 11 | C8H17N4OBr | CAS No. 1086639-59-9
Description: Potent and selective FAK inhibitor
Chemical Name: 1-(2-Hydroxyethyl)-3,5,7-triaza-1-azaniatricyclo[3.3.1.13,7]decane bromide
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Potent inhibitor of focal adhesion kinase (FAK); prevents FAK autophosphorylation at the Y397 site (IC50 ~ 50 nM in an in vitro kinase assay). Displays selectivity for FAK over a panel of other kinases (concentration used in assay = 1 μM). Decreases cell viability in a number of cancer cell lines; blocks colony formation in SW620 and BT474 cell lines.

Compound Libraries

Y 11 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox II. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 265.15
Formula C8H17N4OBr
Storage Store at -20°C
CAS Number 1086639-59-9
PubChem ID 24195918
InChI Key HBPXFHNNLMCUPA-UHFFFAOYSA-M
Smiles OCC[N+]1(CN3C2)CN(C3)CN2C1.[Br-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 26.52 100
DMSO 26.52 100

Preparing Stock Solutions

The following data is based on the product molecular weight 265.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.77 mL 18.86 mL 37.71 mL
5 mM 0.75 mL 3.77 mL 7.54 mL
10 mM 0.38 mL 1.89 mL 3.77 mL
50 mM 0.08 mL 0.38 mL 0.75 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Golubovskaya et al (2012) A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl) -3, 5, 7-triaza-1-azoniatricyclo [3.3.1.13,7]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonoge Carcinogenesis PMID: 22402131

Golubovskaya et al (2008) A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the Y397 site of focal adhesion kinase decreases tumor growth. J.Med.Chem. 51 7405 PMID: 18989950


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View Related Products by Product Action

View all Focal Adhesion Kinase Inhibitors

Keywords: Y 11, Y 11 supplier, potent, focal, adhesion, kinase, FAK, inhibits, inhibitors, autophosphorylation, selective, Y11, Focal, Adhesion, Kinase, 4498, Tocris Bioscience

2 Citations for Y 11

Citations are publications that use Tocris products. Selected citations for Y 11 include:

Robinson et al (2015) Segmentation of Image Data from Complex Organotypic 3D Models of Cancer Tissues with Markov Random Fields. PLoS One 10 e0143798 PMID: 26630674

Brown et al (2015) Notch3 overexpression promotes anoikis resistance in epithelial ovarian cancer via upregulation of COL4A2. Mol Cancer Res 13 78 PMID: 25169943


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Literature in this Area

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Cancer

Cancer Research Product Guide

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