Xenin 8

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Cat.No. 2138 - Xenin 8 | His-Pro-Lys-Arg-Pro-Trp-Ile-Leu | CAS No. 117442-28-1
Description: Neurotensin-like peptide; potentiates insulin and glucagon secretion
Alternative Names: Xenopsin-related peptide 1, XP-1

Biological Activity

C-Terminal fragment of xenin, a neurotensin-like peptide; modulates pancreatic insulin and glucagon secretion/effects. Stimulates basal and arginine-induced insulin secretion and potentiates the insulin response to glucose (EC50 = 0.16 nM). Also potentiates arginine- and carbachol-induced glucagon secretion in a somatostatin-independent manner.

Technical Data

M. Wt 1046.28
Formula C51H79N15O9
Storage Desiccate at -20°C
CAS Number 117442-28-1
PubChem ID 90488740
Smiles [H]N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1046.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.96 mL 4.78 mL 9.56 mL
5 mM 0.19 mL 0.96 mL 1.91 mL
10 mM 0.1 mL 0.48 mL 0.96 mL
50 mM 0.02 mL 0.1 mL 0.19 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Carraway et al (1988) Xenopsin-related peptide generated in avian gastric extracts. Regul.Pept. 22 303 PMID: 2460902

Feurle et al (2003) Metabolism and potency of xenin and of its reduced hexapseudopeptide ψ fragment in dog. Life Sci. 74 697 PMID: 14654163

Silvestre et al (2003) Stimulatory effect of xenin-8 on insulin and glucagon secretion in the perfused rat pancreas. Regul.Pept. 115 25 PMID: 12873795

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