Xenin 8

Pricing Availability Delivery Time Qty
Cat.No. 2138 - Xenin 8 | His-Pro-Lys-Arg-Pro-Trp-Ile-Leu | CAS No. 117442-28-1
Description: Neurotensin-like peptide; potentiates insulin and glucagon secretion
Alternative Names: Xenopsin-related peptide 1, XP-1
Datasheet
Citations

Biological Activity

C-Terminal fragment of xenin, a neurotensin-like peptide; modulates pancreatic insulin and glucagon secretion/effects. Stimulates basal and arginine-induced insulin secretion and potentiates the insulin response to glucose (EC50 = 0.16 nM). Also potentiates arginine- and carbachol-induced glucagon secretion in a somatostatin-independent manner.

Technical Data

M. Wt 1046.28
Formula C51H79N15O9
Sequence HPKRPWIL
Storage Desiccate at -20°C
CAS Number 117442-28-1
PubChem ID 90488740
InChI Key QNDRYLNMRDPBTI-OBOKMFOZSA-N
Smiles [H]N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1046.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.96 mL 4.78 mL 9.56 mL
5 mM 0.19 mL 0.96 mL 1.91 mL
10 mM 0.1 mL 0.48 mL 0.96 mL
50 mM 0.02 mL 0.1 mL 0.19 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Carraway et al (1988) Xenopsin-related peptide generated in avian gastric extracts. Regul.Pept. 22 303 PMID: 2460902

Feurle et al (2003) Metabolism and potency of xenin and of its reduced hexapseudopeptide ψ fragment in dog. Life Sci. 74 697 PMID: 14654163

Silvestre et al (2003) Stimulatory effect of xenin-8 on insulin and glucagon secretion in the perfused rat pancreas. Regul.Pept. 115 25 PMID: 12873795


If you know of a relevant reference for Xenin 8, please let us know.

View Related Products by Target

Keywords: Neurotensin-like peptide potentiates insulin glucagon secretion NT Receptors Xenin8 Xenopsin related peptide1 Xenopsin-related peptide 1 XP-1 Neurotensin Receptor Peptide

Citations for Xenin 8

Citations are publications that use Tocris products.

Currently there are no citations for Xenin 8. Do you know of a great paper that uses Xenin 8 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Pathways for Xenin 8

Protocols

TODO: Add Protocols