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C-Terminal fragment of xenin, a neurotensin-like peptide; modulates pancreatic insulin and glucagon secretion/effects. Stimulates basal and arginine-induced insulin secretion and potentiates the insulin response to glucose (EC50 = 0.16 nM). Also potentiates arginine- and carbachol-induced glucagon secretion in a somatostatin-independent manner.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Carraway et al (1988) Xenopsin-related peptide generated in avian gastric extracts. Regul.Pept. 22 303 PMID: 2460902
Feurle et al (2003) Metabolism and potency of xenin and of its reduced hexapseudopeptide ψ fragment in dog. Life Sci. 74 697 PMID: 14654163
Silvestre et al (2003) Stimulatory effect of xenin-8 on Ins and glucagon secretion in the perfused rat pancreas. Regul.Pept. 115 25 PMID: 12873795
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Keywords: Xenin 8, Xenin 8 supplier, Neurotensin-like, peptide, potentiates, insulin, glucagon, secretion, NT, Receptors, Xenin8, Xenopsin, related, peptide1, Xenopsin-related, 1, XP-1, Neurotensin, 2138, Tocris Bioscience
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Literature in this Area
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.