Xenin 8

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Cat.No. 2138 - Xenin 8 | His-Pro-Lys-Arg-Pro-Trp-Ile-Leu | CAS No. 117442-28-1
Description: Neurotensin-like peptide; potentiates insulin and glucagon secretion
Alternative Names: Xenopsin-related peptide 1, XP-1
Literature (3)

Biological Activity

C-Terminal fragment of xenin, a neurotensin-like peptide; modulates pancreatic insulin and glucagon secretion/effects. Stimulates basal and arginine-induced insulin secretion and potentiates the insulin response to glucose (EC50 = 0.16 nM). Also potentiates arginine- and carbachol-induced glucagon secretion in a somatostatin-independent manner.

Technical Data

M. Wt 1046.28
Formula C51H79N15O9
Storage Desiccate at -20°C
CAS Number 117442-28-1
PubChem ID 90488740
Smiles [H]N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Carraway et al (1988) Xenopsin-related peptide generated in avian gastric extracts. Regul.Pept. 22 303 PMID: 2460902

Feurle et al (2003) Metabolism and potency of xenin and of its reduced hexapseudopeptide ψ fragment in dog. Life Sci. 74 697 PMID: 14654163

Silvestre et al (2003) Stimulatory effect of xenin-8 on Ins and glucagon secretion in the perfused rat pancreas. Regul.Pept. 115 25 PMID: 12873795

If you know of a relevant reference for Xenin 8, please let us know.

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