XEN 445

Discontinued Product

XEN 445 (Cat. No. 5839) has been withdrawn from sale for commercial reasons.
Description: Selective endothelial lipase inhibitor; orally bioavailable
Chemical Name: 2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoic acid
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for XEN 445

XEN 445 is a selective endothelial lipase (EL) inhibitor (IC50 = 237 nM for human EL). Exhibits >20-fold selectivity for EL over lipoprotein lipase (LPL) and hepatic lipase (HL). Increases high density lipoprotein cholesterol (HDLc) plasma levels in mice. Orally bioavailable.

Technical Data for XEN 445

M. Wt 366.33
Formula C18H17F3N2O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1515856-92-4
PubChem ID 72736173
Smiles OC(C1=C(N2CC[C@H](OCC3=CC=CC=N3)C2)C=CC(C(F)(F)F)=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for XEN 445

References are publications that support the biological activity of the product.

Sun et al (2013) Discovery of XEN445: a potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice. Bioorg.Med.Chem. 21 7724 PMID: 24211162

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Keywords: XEN 445, XEN 445 supplier, XEN445, Selective, endothelial, lipase, EL, inhibitors, inhibits, orally, bioavailable, Lipases, 5839, Tocris Bioscience

Citations for XEN 445

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Currently there are no citations for XEN 445.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Cannabinoid Receptor Ligands Scientific Review

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.