XAC

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Description: Adenosine receptor antagonist
Alternative Names: Xanthine amine congener
Chemical Name: N-(2-Aminoethyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-acetamide dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (7)
Reviews

Biological Activity for XAC

XAC is an adenosine receptor antagonist (IC50 values are 1.8 and 114 nM at A1 and A2 receptors respectively). Attenuates adenosine-induced vasodilation and exhibits proconvulsant activity in vivo.

Compound Libraries for XAC

XAC is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for XAC

M. Wt 501.41
Formula C21H28N6O4.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1962928-23-9
PubChem ID 121513846
InChI Key KGNTWECSNGWFKE-UHFFFAOYSA-N
Smiles O=C1N(CCC)C(C(NC(C3=CC=C(OCC(NCCN)=O)C=C3)=N2)=C2N1CCC)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for XAC

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50.14 100

Preparing Stock Solutions for XAC

The following data is based on the product molecular weight 501.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.99 mL 9.97 mL 19.94 mL
5 mM 0.4 mL 1.99 mL 3.99 mL
10 mM 0.2 mL 1 mL 1.99 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets for XAC

Certificate of Analysis / Product Datasheet
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References for XAC

References are publications that support the biological activity of the product.

Morgan et al (1989) Potent convulsant actions of the adenosine receptor antagonist, xanthine amine congener (XAC) Life Sci. 45 719 PMID: 2779359

Sawmiller et al (1994) Effects of xanthine amine congener on hypoxic coronary resistance and venous and epicardial adenosine concentrations. Cardiovasc.Res. 28 604 PMID: 8025903

Wei beta and Grisshammer (2002) Purification and characterization of the human adenosine A2A receptor functionally expressed in Escherichia coli. Eur.J.Biochem. 269 82 PMID: 11784301


If you know of a relevant reference for XAC, please let us know.

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Keywords: XAC, XAC supplier, adenosine, receptors, antagonists, A1, A2, non-selective, xanthene, amine, congener, Xanthine, Non-selective, Adenosine, 3200, Tocris Bioscience

7 Citations for XAC

Citations are publications that use Tocris products. Selected citations for XAC include:

Stoddart et al (2015) Application of BRET to monitor ligand binding to GPCRs. Nat Methods 12 661 PMID: 26030448

Sousa et al (2011) Regulation of hippocampal cannabinoid CB1 receptor actions by adenosine A1 receptors and chronic caffeine administration: implications for the effects of δ9-tetrahydrocannabinol on spatial memory. Neuropsychopharmacology 36 472 PMID: 20927050

Canas et al (2019) Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions. Eneuro 5 PMID: 30627646

Kozma et al (2013) Characterization by flow cytometry of fluorescent, selective agonist probes of the A(3) adenosine receptor. Biochem Pharmacol 85 1171 PMID: 23376019


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