Adenosine receptor antagonist (IC50 values are 1.8 and 114 nM at A1 and A2 receptors respectively). Attenuates adenosine-induced vasodilation and exhibits proconvulsant activity in vivo.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 501.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.99 mL||9.97 mL||19.94 mL|
|5 mM||0.4 mL||1.99 mL||3.99 mL|
|10 mM||0.2 mL||1 mL||1.99 mL|
|50 mM||0.04 mL||0.2 mL||0.4 mL|
References are publications that support the products' biological activity.
Morgan et al (1989) Potent convulsant actions of the adenosine receptor antagonist, xanthine amine congener (XAC) Life Sci. 45 719 PMID: 2779359
Sawmiller et al (1994) Effects of xanthine amine congener on hypoxic coronary resistance and venous and epicardial adenosine concentrations. Cardiovasc.Res. 28 604 PMID: 8025903
Wei beta and Grisshammer (2002) Purification and characterization of the human adenosine A2A receptor functionally expressed in Escherichia coli. Eur.J.Biochem. 269 82 PMID: 11784301
If you know of a relevant reference for XAC, please let us know.
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Keywords: XAC, supplier, adenosine, receptors, antagonists, A1, A2, non-selective, Xanthine, amine, congener, Non-selective, Adenosine, Non-selective, Adenosine, Tocris Bioscience
3 Citations for XAC
Citations are publications that use Tocris products. Selected citations for XAC include:
Stoddart et al (2015) Application of BRET to monitor ligand binding to GPCRs. Nat Methods 12 661 PMID: 26030448
Kaster et al (2015) Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress. Hepatology 112 7833 PMID: 26056314
Kozma et al (2013) Characterization by flow cytometry of fluorescent, selective agonist probes of the A(3) adenosine receptor. Biochem Pharmacol 85 1171 PMID: 23376019
Do you know of a great paper that uses XAC from Tocris? If so please let us know.
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