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WZ 811

Cat. No. 3951 Submit a Review Datasheet / COA / SDS
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Cat.No. 3951 - WZ 811 | C18H18N4 | CAS No. 55778-02-4
Description: Potent CXCR4 antagonist
Chemical Name: N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (4)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent chemokine receptor type 4 (CXCR4) antagonist (EC50 = 0.3 nM). Inhibits CXCR4/stromal cell-derived factor-1 (SDF-1)-mediated modulation of cAMP in vitro (EC50 = 1.2 nM).

Technical Data

M. Wt 290.36
Formula C18H18N4
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 55778-02-4
PubChem ID 11565518
InChI Key KBVFRXIGQQRMEF-UHFFFAOYSA-N
Smiles C1(CNC3=NC=CC=C3)=CC=C(CNC2=NC=CC=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.26 25

Preparing Stock Solutions

The following data is based on the product molecular weight 290.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 13.78 mL 68.88 mL 137.76 mL
1.25 mM 2.76 mL 13.78 mL 27.55 mL
2.5 mM 1.38 mL 6.89 mL 13.78 mL
12.5 mM 0.28 mL 1.38 mL 2.76 mL

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References

References are publications that support the biological activity of the product.

Zhan et al (2007) Discovery of small molecule CXCR4 antagonists. J.Med.Chem. 50 5655 PMID: 17958344

Reyes et al (2002) Pyridinium N-(2'-azinyl)aminides: regioselective synthesis of N-(2-pyridyl) substituted polyamines. Chem.Inform. 34

If you know of a relevant reference for WZ 811, please let us know.

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Citations for WZ 811

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