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Potent chemokine receptor type 4 (CXCR4) antagonist (EC50 = 0.3 nM). Inhibits CXCR4/stromal cell-derived factor-1 (SDF-1)-mediated modulation of cAMP in vitro (EC50 = 1.2 nM).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 290.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.25 mM||13.78 mL||68.88 mL||137.76 mL|
|1.25 mM||2.76 mL||13.78 mL||27.55 mL|
|2.5 mM||1.38 mL||6.89 mL||13.78 mL|
|12.5 mM||0.28 mL||1.38 mL||2.76 mL|
References are publications that support the biological activity of the product.
Zhan et al (2007) Discovery of small molecule CXCR4 antagonists. J.Med.Chem. 50 5655 PMID: 17958344
Reyes et al (2002) Pyridinium N-(2'-azinyl)aminides: regioselective synthesis of N-(2-pyridyl) substituted polyamines. Chem.Inform. 34
If you know of a relevant reference for WZ 811, please let us know.
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Keywords: WZ 811, WZ 811 supplier, WZ811, chemokine, receptors, receptor, type, 4, antagonists, CXCR4, Chemokine, CXC, Receptors, 3951, Tocris Bioscience
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Rheumatoid Arthritis Poster
Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.