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Potent inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50 = 70 nM), an enzyme which catalyzes the hydrolysis of 2-arachidonylglycerol (Cat. No. 1298).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 437.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||22.86 mL||114.29 mL||228.58 mL|
|0.5 mM||4.57 mL||22.86 mL||45.72 mL|
|1 mM||2.29 mL||11.43 mL||22.86 mL|
|5 mM||0.46 mL||2.29 mL||4.57 mL|
References are publications that support the biological activity of the product.
Blankman et al (2007) A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonylglycerol. Chem.Biol. 14 1347 PMID: 18096503
Li et al (2007) A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases. J.Am.Chem.Soc. 129 9594 PMID: 17629278
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1 Citation for WWL 70
Citations are publications that use Tocris products. Selected citations for WWL 70 include:
Tchantchou and Zhang (2013) Selective inhibition of alpha/beta-hydrolase domain 6 attenuates neurodegeneration, alleviates blood brain barrier breakdown, and improves functional recovery in a mouse model of traumatic brain injury. J Neurotrauma 30 565 PMID: 23151067
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Literature in this Area
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