WWL 70

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Cat.No. 3252 - WWL 70 | C27H23N3O3 | CAS No. 947669-91-2
Description: Potent ABHD6 inhibitor
Chemical Name: N-Methyl-N-[[3-(4-pyridinyl)phenyl]methyl]-4'-(aminocarbonyl)[1,1'-biphenyl]-4-yl carbamic acid ester
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)

Biological Activity

Potent inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50 = 70 nM), an enzyme which catalyzes the hydrolysis of 2-arachidonylglycerol (Cat. No. 1298).

Technical Data

M. Wt 437.49
Formula C27H23N3O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 947669-91-2
PubChem ID 17759121
InChI Key QTWNORFUQILKJL-UHFFFAOYSA-N
Smiles O=C(N(C)CC2=CC(C4=CC=NC=C4)=CC=C2)OC1=CC=C(C3=CC=C(C(N)=O)C=C3)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.37 10

Preparing Stock Solutions

The following data is based on the product molecular weight 437.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.86 mL 114.29 mL 228.58 mL
0.5 mM 4.57 mL 22.86 mL 45.72 mL
1 mM 2.29 mL 11.43 mL 22.86 mL
5 mM 0.46 mL 2.29 mL 4.57 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Blankman et al (2007) A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonylglycerol. Chem.Biol. 14 1347 PMID: 18096503

Li et al (2007) A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases. J.Am.Chem.Soc. 129 9594 PMID: 17629278


If you know of a relevant reference for WWL 70, please let us know.

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View all Other Hydrolase Inhibitors

Keywords: WWL 70, WWL 70 supplier, WWL70, potent, ABHD6, inhibitors, αβ-hydrolase, domain, 6, alphabeta-hydrolase, endocannabinoids, 2-arachidonylglycerol, hydrolysis, inhibits, Other, Hydrolases, Cannabinoids, 3252, Tocris Bioscience

1 Citation for WWL 70

Citations are publications that use Tocris products. Selected citations for WWL 70 include:

Tchantchou and Zhang (2013) Selective inhibition of alpha/beta-hydrolase domain 6 attenuates neurodegeneration, alleviates blood brain barrier breakdown, and improves functional recovery in a mouse model of traumatic brain injury. J Neurotrauma 30 565 PMID: 23151067


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Literature in this Area

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