WWL 113

Discontinued Product

WWL 113 (Cat. No. 5259) has been withdrawn from sale for commercial reasons.
Cat.No. 5259 - WWL 113 | C29H26N2O4 | CAS No. 947669-86-5
Description: Ces3 and Ces1f inhibitor
Chemical Name: 4'-[[[Methyl[[3-(4-pyridinyl)phenyl]methyl]amino]carbonyl]oxy]-[1,1'-biphenyl]-4-carboxylic acid ethyl ester
Purity: ≥99% (HPLC)
Citations (1)

Biological Activity for WWL 113

WWL 113 is a carboxylesterase Ces3 and Ces1f inhibitor (IC50 values are ~100 nM). Also inhibits ABHD6. Exhibits minimal activity against a panel of other serine hydrolases. Promotes lipid storage in adipocytes. Reduces weight gain in diet-induced obese mice and enhances glucose tolerance in diabetic mice. Orally active.

Technical Data for WWL 113

M. Wt 466.53
Formula C29H26N2O4
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 947669-86-5
PubChem ID 17759482
Smiles CN(C(OC3=CC=C(C4=CC=C(C(OCC)=O)C=C4)C=C3)=O)CC1=CC=CC(C2=CC=NC=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for WWL 113

References are publications that support the biological activity of the product.

Dominguez et al (2014) Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes. Nat.Chem.Biol. 10 113 PMID: 24362705

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Keywords: WWL 113, WWL 113 supplier, WWL113, carboxyesterases, Ces3, ces1d, cesif, ABHD6, hydrolases, serine, lipids, metabolism, obesity, diabetes, Other, Hydrolases, Lipid, Metabolism, 5259, Tocris Bioscience

1 Citation for WWL 113

Citations are publications that use Tocris products. Selected citations for WWL 113 include:

Patra et al (2018) Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism. Nat Cell Biol 20 811 PMID: 29941929

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