WWL 113

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Cat.No. 5259 - WWL 113 | C29H26N2O4 | CAS No. 947669-86-5
Description: Ces3 and Ces1f inhibitor
Chemical Name: 4'-[[[Methyl[[3-(4-pyridinyl)phenyl]methyl]amino]carbonyl]oxy]-[1,1'-biphenyl]-4-carboxylic acid ethyl ester
Purity: ≥99% (HPLC)

Biological Activity

Carboxylesterase Ces3 and Ces1f inhibitor (IC50 values are ~100 nM). Also inhibits ABHD6. Exhibits minimal activity against a panel of other serine hydrolases. Promotes lipid storage in adipocytes. Reduces weight gain in diet-induced obese mice and enhances glucose tolerance in diabetic mice. Orally active.

Compound Libraries

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Technical Data

M. Wt 466.53
Formula C29H26N2O4
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 947669-86-5
PubChem ID 17759482
Smiles CN(C(OC3=CC=C(C4=CC=C(C(OCC)=O)C=C4)C=C3)=O)CC1=CC=CC(C2=CC=NC=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 23.33 50

Preparing Stock Solutions

The following data is based on the product molecular weight 466.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.29 mL 21.43 mL 42.87 mL
2.5 mM 0.86 mL 4.29 mL 8.57 mL
5 mM 0.43 mL 2.14 mL 4.29 mL
25 mM 0.09 mL 0.43 mL 0.86 mL

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References are publications that support the biological activity of the product.

Dominguez et al (2014) Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes. Nat.Chem.Biol. 10 113 PMID: 24362705

If you know of a relevant reference for WWL 113, please let us know.

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Keywords: WWL 113, WWL 113 supplier, WWL113, carboxyesterases, Ces3, ces1d, cesif, ABHD6, hydrolases, serine, lipids, metabolism, obesity, diabetes, Other, Hydrolases, Lipid, Metabolism, 5259, Tocris Bioscience

Citations for WWL 113

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