WWL 113

Pricing Availability   Qty
Cat.No. 5259 - WWL 113 | C29H26N2O4 | CAS No. 947669-86-5
Description: Ces3 and Ces1f inhibitor
Chemical Name: 4'-[[[Methyl[[3-(4-pyridinyl)phenyl]methyl]amino]carbonyl]oxy]-[1,1'-biphenyl]-4-carboxylic acid ethyl ester
Purity: ≥99% (HPLC)
Citations (1)

Biological Activity

Carboxylesterase Ces3 and Ces1f inhibitor (IC50 values are ~100 nM). Also inhibits ABHD6. Exhibits minimal activity against a panel of other serine hydrolases. Promotes lipid storage in adipocytes. Reduces weight gain in diet-induced obese mice and enhances glucose tolerance in diabetic mice. Orally active.

Technical Data

M. Wt 466.53
Formula C29H26N2O4
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 947669-86-5
PubChem ID 17759482
Smiles CN(C(OC3=CC=C(C4=CC=C(C(OCC)=O)C=C4)C=C3)=O)CC1=CC=CC(C2=CC=NC=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 23.33 50

Preparing Stock Solutions

The following data is based on the product molecular weight 466.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.29 mL 21.43 mL 42.87 mL
2.5 mM 0.86 mL 4.29 mL 8.57 mL
5 mM 0.43 mL 2.14 mL 4.29 mL
25 mM 0.09 mL 0.43 mL 0.86 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.


References are publications that support the biological activity of the product.

Dominguez et al (2014) Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes. Nat.Chem.Biol. 10 113 PMID: 24362705

If you know of a relevant reference for WWL 113, please let us know.

View Related Products by Product Action

View all Other Lipid Metabolism Inhibitors

Keywords: WWL 113, WWL 113 supplier, WWL113, carboxyesterases, Ces3, ces1d, cesif, ABHD6, hydrolases, serine, lipids, metabolism, obesity, diabetes, Other, Hydrolases, Lipid, Metabolism, 5259, Tocris Bioscience

1 Citation for WWL 113

Citations are publications that use Tocris products. Selected citations for WWL 113 include:

Patra et al (2018) Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism. Nat Cell Biol 20 811 PMID: 29941929

Do you know of a great paper that uses WWL 113 from Tocris? Please let us know.

Reviews for WWL 113

There are currently no reviews for this product. Be the first to review WWL 113 and earn rewards!

Have you used WWL 113?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review