WM 3835

Pricing Availability   Qty
Description: Lysine acetyltransferase HBO1 (KAT7) inhibitor
Chemical Name: N'-(4-Fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)-3-hydroxybenzenesulfonohydrazide
Purity: ≥98% (HPLC)
Citations (1)
Literature (3)

Biological Activity for WM 3835

WM 3835 is a lysine acetyltransferase HBO1 (KAT7) inhibitor. Reduces H3K14ac levels and inhibits growth and viability of acute myeloid leukemia cell lines in vitro. Cell-permeable.

Compound Libraries for WM 3835

WM 3835 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for WM 3835

M. Wt 400.42
Formula C20H17FN2O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2229025-70-9
PubChem ID 134581412
Smiles CC1=CC(C2=CC=CC=C2)=CC(C(NNS(=O)(C3=CC(O)=CC=C3)=O)=O)=C1F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for WM 3835

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 40.04 100
ethanol 20.02 50

Preparing Stock Solutions for WM 3835

The following data is based on the product molecular weight 400.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.5 mL 12.49 mL 24.97 mL
5 mM 0.5 mL 2.5 mL 4.99 mL
10 mM 0.25 mL 1.25 mL 2.5 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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References for WM 3835

References are publications that support the biological activity of the product.

MacPherson et al (2019) HBO1 is required for the maintenance of leukaemia stem cells. Nature 577 299 PMID: 31827282

If you know of a relevant reference for WM 3835, please let us know.

View Related Products by Target

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View all Histone Acetyltransferase Inhibitors

Keywords: WM 3835, WM 3835 supplier, WM3835, Lysine, acetyl, transferase, inhibitors, inhibits, KAT7, HBO1, histone, HATs, MYST2, Histone, Acetyltransferases, 7366, Tocris Bioscience

1 Citation for WM 3835

Citations are publications that use Tocris products. Selected citations for WM 3835 include:

Lancho et al (2023) A therapeutically targetable NOTCH1-SIRT1-KAT7 axis in T-cell leukemia. Blood Cancer Discov. 4 12 PMID: 36322781

Do you know of a great paper that uses WM 3835 from Tocris? Please let us know.

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Literature in this Area

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