Discontinued Product

WKYMVM (Cat. No. 1799) has been withdrawn from sale for commercial reasons.
Description: Selective FPR2 and FPR3 receptor agonist
Alternative Names: W-peptide
Citations (5)

Biological Activity for WKYMVM

WKYMVM is a selective agonist for the formyl peptide receptors FPR2 and FPR3, expressed on immune cells. EC50 values for induction of calcium mobilization in FPR2-HL-60 cells and FPR3-HL-60 cells are 2 and 80 nM respectively.

Technical Data for WKYMVM

M. Wt 856.11
Formula C41H61N9O7S2
Sequence WKYMVM

(Modifications: Met-6 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 187986-11-4
PubChem ID 68661247
Smiles [H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for WKYMVM

Certificate of Analysis / Product Datasheet
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Keywords: WKYMVM, WKYMVM supplier, Selective, FPR2, FPR3, receptor, agonists, FPRL, Formyl, like, Peptide, Receptors, W-peptide, 1799, Tocris Bioscience

5 Citations for WKYMVM

Citations are publications that use Tocris products. Selected citations for WKYMVM include:

García-Prieto et al (2017) Neutrophil stunning by MP reduces infarct size. Nat Commun 8 14780 PMID: 28416795

Schepetkin et al (2014) Antagonism of human formyl peptide receptor 1 (FPR1) by chromones and related isoflavones. Biochem Pharmacol 92 627 PMID: 25450672

Schepetkin et al (2011) Gastrin-releasing peptide/neuromedin B receptor antagonists PD176252, PD168368, and related analogs are potent agonists of human formyl-peptide receptors. Mol Pharmacol 79 77 PMID: 20943772

Kienle et al (2021) Neutrophils self-limit swarming to contain bacterial growth in vivo Science 372 PMID: 34140358

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