WKYMVM

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Cat.No. 1799 - WKYMVM | Trp-Lys-Tyr-Met-Val-Met-NH2 | CAS No. 187986-11-4
Description: Selective FPR2 and FPR3 receptor agonist
Alternative Names: W-peptide
Datasheet
Citations (3)
Literature

Biological Activity

Selective agonist for the formyl peptide receptors FPR2 and FPR3, expressed on immune cells. EC50 values for induction of calcium mobilization in FPR2-HL-60 cells and FPR3-HL-60 cells are 2 and 80 nM respectively.

Technical Data

M. Wt 856.11
Formula C41H61N9O7S2
Sequence WKYMVM

(Modifications: Met-6 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 187986-11-4
PubChem ID 68661247
InChI Key FMBGOORJEKQQLG-LXOXETEGSA-N
Smiles [H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 0.60 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 856.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.17 mL 5.84 mL 11.68 mL
5 mM 0.23 mL 1.17 mL 2.34 mL
10 mM 0.12 mL 0.58 mL 1.17 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Baek et al (1996) Identification of the peptides that stimulate the phosphoinositide hydrolysis in lymphocyte cell lines from peptide libraries. J.Biol.Chem. 271 8170 PMID: 8626507

Christophe et al (2001) The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/Lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. J.Biol.Chem. 276 21585 PMID: 11285256

Christophe et al (2002) Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1 /LXA4R, is not affected by lipoxin. Scand.J.Immunol. 56 470 PMID: 12410796


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Keywords: WKYMVM, supplier, Selective, FPR2, FPR3, receptor, agonists, FPRL, Formyl, like, Peptide, Receptors, W-peptide, Formyl, Peptide, Receptors, Tocris Bioscience

3 Citations for WKYMVM

Citations are publications that use Tocris products. Selected citations for WKYMVM include:

Schepetkin et al (2011) Gastrin-releasing peptide/neuromedin B receptor antagonists PD176252, PD168368, and related analogs are potent agonists of human formyl-peptide receptors. Mol Pharmacol 79 77 PMID: 20943772

Schepetkin et al (2014) Antagonism of human formyl peptide receptor 1 (FPR1) by chromones and related isoflavones. Biochem Pharmacol 92 627 PMID: 25450672

Schepetkin et al (2013) 3-(1H-indol-3-yl)-2-[3-(4-nitrophenyl)ureido]propanamide enantiomers with human formyl-peptide receptor agonist activity: molecular modeling of chiral recognition by FPR2. Biochem Pharmacol 85 404 PMID: 23219934


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