WAY 207024 dihydrochloride

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Cat.No. 3890 - WAY 207024 dihydrochloride | C30H32N6.2HCl | CAS No. 872002-73-8
Description: GnRH receptor antagonist
Chemical Name: 6-[[4-[2-[4-(1,1-Dimethylethyl)phenyl]-1H-benzimidazol-7-yl]-i-piperazinyl]methyl]-quinoxaline dihydrochloride
Purity: ≥99% (HPLC)
Literature (2)

Biological Activity for WAY 207024 dihydrochloride

WAY 207024 dihydrochloride is a gonadotropin releasing hormone receptor (GnRH-R) antagonist. Exhibits potent affinity (IC50 values are 12 and 71 nM for human and rat GnRH receptors respectively). Lowers plasma leuteinizing hormone levels in the rat. Orally active.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for WAY 207024 dihydrochloride

M. Wt 549.54
Formula C30H32N6.2HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 872002-73-8
PubChem ID 69403574
Smiles CC(C)(C)C(C=C6)=CC=C6C(N5)=NC1=C5C(N(CC4)CCN4CC2=CC=C(N=CC=N3)C3=C2)=CC=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for WAY 207024 dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 46.71 85

Preparing Stock Solutions for WAY 207024 dihydrochloride

The following data is based on the product molecular weight 549.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.85 mM 2.14 mL 10.7 mL 21.41 mL
4.25 mM 0.43 mL 2.14 mL 4.28 mL
8.5 mM 0.21 mL 1.07 mL 2.14 mL
42.5 mM 0.04 mL 0.21 mL 0.43 mL

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Product Datasheets for WAY 207024 dihydrochloride

References for WAY 207024 dihydrochloride

References are publications that support the biological activity of the product.

Pelletier et al (2009) Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the g.tropin releasing hormone receptor (GnRH-R). J.Med.Chem. 52 214 PMID: 19072222

If you know of a relevant reference for WAY 207024 dihydrochloride, please let us know.

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