WAY 207024 dihydrochloride

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Cat.No. 3890 - WAY 207024 dihydrochloride | C30H32N6.2HCl | CAS No. 872002-73-8
Description: GnRH receptor antagonist
Chemical Name: 6-[[4-[2-[4-(1,1-Dimethylethyl)phenyl]-1H-benzimidazol-7-yl]-i-piperazinyl]methyl]-quinoxaline dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Gonadotropin releasing hormone receptor (GnRH-R) antagonist. Exhibits potent affinity (IC50 values are 12 and 71 nM for human and rat GnRH receptors respectively). Lowers plasma leuteinizing hormone levels in the rat. Orally active.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

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Technical Data

M. Wt 549.54
Formula C30H32N6.2HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 872002-73-8
PubChem ID 69403574
InChI Key REQCNTGYEABOIT-UHFFFAOYSA-N
Smiles CC(C)(C)C(C=C6)=CC=C6C(N5)=NC1=C5C(N(CC4)CCN4CC2=CC=C(N=CC=N3)C3=C2)=CC=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.71 85

Preparing Stock Solutions

The following data is based on the product molecular weight 549.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.85 mM 2.14 mL 10.7 mL 21.41 mL
4.25 mM 0.43 mL 2.14 mL 4.28 mL
8.5 mM 0.21 mL 1.07 mL 2.14 mL
42.5 mM 0.04 mL 0.21 mL 0.43 mL

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References

References are publications that support the biological activity of the product.

Pelletier et al (2009) Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). J.Med.Chem. 52 214 PMID: 19072222


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