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Calmodulin antagonist (inhibits calmodulin-activated PDE activity with an IC50 of 72 μM).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 377.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.25 mM||10.6 mL||53 mL||106.01 mL|
|1.25 mM||2.12 mL||10.6 mL||21.2 mL|
|2.5 mM||1.06 mL||5.3 mL||10.6 mL|
|12.5 mM||0.21 mL||1.06 mL||2.12 mL|
References are publications that support the biological activity of the product.
Hidaka et al (1979) Selective inhibitors of Ca2+-binding modulator of phosphodiesterase produce vascular relaxation and inhibit actin-myosin interaction. Mol.Pharmacol. 15 49 PMID: 218093
Hidaka et al (1981) N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation. Proc.Natl.Acad.Sci.U.S.A. 78 4354 PMID: 6945588
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Keywords: W-9 hydrochloride, W-9 hydrochloride supplier, Calmodulin, antagonists, Ca2+, Binding, Protein, modulators, Calcium, Signaling, Signalling, Ca2+-calmodulin-dependent, phosphodiesterase, 0370, Tocris Bioscience
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