W-9 hydrochloride

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Cat.No. 0370 - W-9 hydrochloride | C16H21ClN2O2S.HCl | CAS No. 69762-85-2
Description: Calmodulin antagonist
Chemical Name: N-(6-Aminohexyl)-5-chloro-2-naphthalenesulfonamide hydrochloride

Biological Activity

Calmodulin antagonist (inhibits calmodulin-activated PDE activity with an IC50 of 72 μM).

Technical Data

M. Wt 377.33
Formula C16H21ClN2O2S.HCl
Storage Store at RT
CAS Number 69762-85-2
PubChem ID 2735339
Smiles Cl.NCCCCCCNS(=O)(=O)C1=CC=C2C(Cl)=CC=CC2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 25

Preparing Stock Solutions

The following data is based on the product molecular weight 377.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 10.6 mL 53 mL 106.01 mL
1.25 mM 2.12 mL 10.6 mL 21.2 mL
2.5 mM 1.06 mL 5.3 mL 10.6 mL
12.5 mM 0.21 mL 1.06 mL 2.12 mL

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References are publications that support the biological activity of the product.

Hidaka et al (1979) Selective inhibitors of Ca2+-binding modulator of phosphodiesterase produce vascular relaxation and inhibit actin-myosin interaction. Mol.Pharmacol. 15 49 PMID: 218093

Hidaka et al (1981) N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation. Proc.Natl.Acad.Sci.U.S.A. 78 4354 PMID: 6945588

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