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Calmodulin antagonist (inhibits Ca2+-calmodulin dependent PDE with an IC50 of 240 μM).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 342.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.83 mL||29.16 mL||58.33 mL|
|2.5 mM||1.17 mL||5.83 mL||11.67 mL|
|5 mM||0.58 mL||2.92 mL||5.83 mL|
|25 mM||0.12 mL||0.58 mL||1.17 mL|
References are publications that support the biological activity of the product.
Hidaka et al (1981) Activity-structure relationship of calmodulin antagonists. Naphthalenesulfonamide derivatives. Mol.Pharmacol. 20 571 PMID: 7329399
Hidaka et al (1981) N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation. Proc.Natl.Acad.Sci.U.S.A. 78 4354 PMID: 6945588
Hidaka and Tanaka (1983) Naphthalenesulfonamides as calmodulin antagonists. Methods Enzymol. 102 185 PMID: 6139736
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Keywords: W-5 hydrochloride, W-5 hydrochloride supplier, Calmodulin, antagonists, Ca2+, Binding, Protein, modulators, Calcium, Signaling, Signalling, 0368, Tocris Bioscience
1 Citation for W-5 hydrochloride
Citations are publications that use Tocris products. Selected citations for W-5 hydrochloride include:
Long et al (2009) Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release. PLoS Biol 284 8726 PMID: 19141616
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