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W-5 hydrochloride

Cat. No. 0368 1 Citation Submit a Review Datasheet / COA / SDS

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0368 has been discontinued.

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Description: Calmodulin antagonist
Chemical Name: N-(6-Aminohexyl)-1-naphthalenesulfonamide hydrochloride
Datasheet
Citations (1)
Reviews
Biological Activity Technical Data Datasheets References

Biological Activity for W-5 hydrochloride

W-5 hydrochloride is a calmodulin antagonist (inhibits Ca2+-calmodulin dependent PDE with an IC50 of 240 μM).

Technical Data for W-5 hydrochloride

M. Wt 342.88
Formula C16H22N2O2S.HCl
Storage Store at RT
CAS Number 61714-25-8
PubChem ID 173829
InChI Key HOCSVIGHWPLMFC-UHFFFAOYSA-N
Smiles Cl.NCCCCCCNS(=O)(=O)C1=C2C=CC=CC2=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for W-5 hydrochloride

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for W-5 hydrochloride

References are publications that support the biological activity of the product.

Hidaka et al (1981) Activity-structure relationship of calmodulin antagonists. Naphthalenesulfonamide derivatives. Mol.Pharmacol. 20 571 PMID: 7329399

Hidaka et al (1981) N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation. Proc.Natl.Acad.Sci.U.S.A. 78 4354 PMID: 6945588

Hidaka and Tanaka (1983) Naphthalenesulfonamides as calmodulin antagonists. Methods Enzymol. 102 185 PMID: 6139736

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Keywords: W-5 hydrochloride, W-5 hydrochloride supplier, Calmodulin, antagonists, Ca2+, Binding, Protein, modulators, Calcium, Signaling, Signalling, 0368, Tocris Bioscience

1 Citation for W-5 hydrochloride

Citations are publications that use Tocris products. Selected citations for W-5 hydrochloride include:

Long et al (2009) Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release. PLoS Biol 284 8726 PMID: 19141616

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