W-5 hydrochloride

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Description: Calmodulin antagonist
Chemical Name: N-(6-Aminohexyl)-1-naphthalenesulfonamide hydrochloride
Citations (1)

Biological Activity for W-5 hydrochloride

W-5 hydrochloride is a calmodulin antagonist (inhibits Ca2+-calmodulin dependent PDE with an IC50 of 240 μM).

Technical Data for W-5 hydrochloride

M. Wt 342.88
Formula C16H22N2O2S.HCl
Storage Store at RT
CAS Number 61714-25-8
PubChem ID 173829
Smiles Cl.NCCCCCCNS(=O)(=O)C1=C2C=CC=CC2=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for W-5 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 17.14 50
water 3.43 10

Preparing Stock Solutions for W-5 hydrochloride

The following data is based on the product molecular weight 342.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.83 mL 29.16 mL 58.33 mL
2.5 mM 1.17 mL 5.83 mL 11.67 mL
5 mM 0.58 mL 2.92 mL 5.83 mL
25 mM 0.12 mL 0.58 mL 1.17 mL

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Product Datasheets for W-5 hydrochloride

Certificate of Analysis / Product Datasheet
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References for W-5 hydrochloride

References are publications that support the biological activity of the product.

Hidaka et al (1981) Activity-structure relationship of calmodulin antagonists. Naphthalenesulfonamide derivatives. Mol.Pharmacol. 20 571 PMID: 7329399

Hidaka et al (1981) N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation. Proc.Natl.Acad.Sci.U.S.A. 78 4354 PMID: 6945588

Hidaka and Tanaka (1983) Naphthalenesulfonamides as calmodulin antagonists. Methods Enzymol. 102 185 PMID: 6139736

If you know of a relevant reference for W-5 hydrochloride, please let us know.

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1 Citation for W-5 hydrochloride

Citations are publications that use Tocris products. Selected citations for W-5 hydrochloride include:

Long et al (2009) Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release. PLoS Biol 284 8726 PMID: 19141616

Do you know of a great paper that uses W-5 hydrochloride from Tocris? Please let us know.

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