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Submit ReviewW-13 hydrochloride
Description: Calmodulin antagonist
Chemical Name: N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for W-13 hydrochloride
W-13 hydrochloride is a calmodulin antagonist (inhibits calmodulin activated PDE activity with an IC50 of 68 μM). Inhibits growth of tamoxifen-resistant breast cancer cells.
Technical Data for W-13 hydrochloride
| M. Wt | 349.27 |
| Formula | C14H17ClN2O2S.HCl |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 88519-57-7 |
| PubChem ID | 16760706 |
| InChI Key | QKAALLVQBOLELJ-UHFFFAOYSA-N |
| Smiles | Cl.NCCCCNS(=O)(=O)C1=CC=C2C(Cl)=CC=CC2=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for W-13 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 34.93 | 100 | |
| DMSO | 34.93 | 100 |
Preparing Stock Solutions for W-13 hydrochloride
The following data is based on the product molecular weight 349.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.86 mL | 14.32 mL | 28.63 mL |
| 5 mM | 0.57 mL | 2.86 mL | 5.73 mL |
| 10 mM | 0.29 mL | 1.43 mL | 2.86 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.57 mL |
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Product Datasheets for W-13 hydrochloride
References for W-13 hydrochloride
References are publications that support the biological activity of the product.
Bosch et al (1998) Calmodulin inhibitor W13 induces sustained activation of ERK2 and expression of p21cip1. J.Biol.Chem. 273 22145 PMID: 9705360
Hidaka and Tanaka (1983) Naphthalenesulfonamides as calmodulin antagonists. Methods Enzymol. 102 185 PMID: 6139736
Stroble and Peterson (1992) Tamoxifen-resistant human breast cancer cell growth: inhibition by thionidazine, pim. and the calmodulin antagonist, W-13. J.Pharmacol.Exp.Ther. 263 186 PMID: 1403784
If you know of a relevant reference for W-13 hydrochloride, please let us know.
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Keywords: W-13 hydrochloride, W-13 hydrochloride supplier, Calmodulin, antagonists, Ca2+, Binding, Protein, modulators, Calcium, Signaling, Signalling, W13, 0361, Tocris Bioscience
2 Citations for W-13 hydrochloride
Citations are publications that use Tocris products. Selected citations for W-13 hydrochloride include:
Sethna et al (2016) Calmodulin activity regulates group I metabotropic glutamate receptor-mediated signal transduction and synaptic depression. J Neurosci Res 94 401 PMID: 26864654
Yanda et al (2017) Histone deacetylase 6 inhibition reduces cysts by decreasing cAMP and Ca(2+) in knock-out mouse models of polycystic kidney disease. J Biol Chem 292 17897 PMID: 28887310
Do you know of a great paper that uses W-13 hydrochloride from Tocris? Please let us know.
Reviews for W-13 hydrochloride
Average Rating: 5 (Based on 1 Review.)
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PN and PH cells were treated with W-7 (catalog no. 0369) and W-13 (catalog no. 0361) purchased from Tocris..
By
Anonymous on 11/17/2019
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: PN and PH cells
PN and PH cells were treated with W-7 (catalog no. 0369) and W-13(catalog no. 0361) purchased from Tocris.
