W-13 hydrochloride

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Cat.No. 0361 - W-13 hydrochloride | C14H17ClN2O2S.HCl | CAS No. 88519-57-7
Description: Calmodulin antagonist
Chemical Name: N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide hydrochloride
Purity: ≥98% (HPLC)

Biological Activity

Calmodulin antagonist (inhibits calmodulin activated PDE activity with an IC50 of 68 μM). Inhibits growth of tamoxifen-resistant breast cancer cells.

Technical Data

M. Wt 349.27
Formula C14H17ClN2O2S.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 88519-57-7
PubChem ID 16760706
Smiles Cl.NCCCCNS(=O)(=O)C1=CC=C2C(Cl)=CC=CC2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 34.93 100
water 34.93 100

Preparing Stock Solutions

The following data is based on the product molecular weight 349.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.86 mL 14.32 mL 28.63 mL
5 mM 0.57 mL 2.86 mL 5.73 mL
10 mM 0.29 mL 1.43 mL 2.86 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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References are publications that support the products' biological activity.

Bosch et al (1998) Calmodulin inhibitor W13 induces sustained activation of ERK2 and expression of p21cip1. J.Biol.Chem. 273 22145 PMID: 9705360

Hidaka and Tanaka (1983) Naphthalenesulfonamides as calmodulin antagonists. Methods Enzymol. 102 185 PMID: 6139736

Stroble and Peterson (1992) Tamoxifen-resistant human breast cancer cell growth: inhibition by thionidazine, pimozide and the calmodulin antagonist, W-13. J.Pharmacol.Exp.Ther. 263 186 PMID: 1403784

If you know of a relevant reference for W-13 hydrochloride, please let us know.

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