Calmodulin antagonist (inhibits calmodulin activated PDE activity with an IC50 of 68 μM). Inhibits growth of tamoxifen-resistant breast cancer cells.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 349.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.86 mL||14.32 mL||28.63 mL|
|5 mM||0.57 mL||2.86 mL||5.73 mL|
|10 mM||0.29 mL||1.43 mL||2.86 mL|
|50 mM||0.06 mL||0.29 mL||0.57 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Bosch et al (1998) Calmodulin inhibitor W13 induces sustained activation of ERK2 and expression of p21cip1. J.Biol.Chem. 273 22145 PMID: 9705360
Hidaka and Tanaka (1983) Naphthalenesulfonamides as calmodulin antagonists. Methods Enzymol. 102 185 PMID: 6139736
Stroble and Peterson (1992) Tamoxifen-resistant human breast cancer cell growth: inhibition by thionidazine, pimozide and the calmodulin antagonist, W-13. J.Pharmacol.Exp.Ther. 263 186 PMID: 1403784
If you know of a relevant reference for W-13 hydrochloride, please let us know.
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Citations for W-13 hydrochloride
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