W-13 hydrochloride

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Cat.No. 0361 - W-13 hydrochloride | C14H17ClN2O2S.HCl | CAS No. 88519-57-7
Description: Calmodulin antagonist
Chemical Name: N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews (1)

Biological Activity

Calmodulin antagonist (inhibits calmodulin activated PDE activity with an IC50 of 68 μM). Inhibits growth of tamoxifen-resistant breast cancer cells.

Technical Data

M. Wt 349.27
Formula C14H17ClN2O2S.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 88519-57-7
PubChem ID 16760706
InChI Key QKAALLVQBOLELJ-UHFFFAOYSA-N
Smiles Cl.NCCCCNS(=O)(=O)C1=CC=C2C(Cl)=CC=CC2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 34.93 100
DMSO 34.93 100

Preparing Stock Solutions

The following data is based on the product molecular weight 349.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.86 mL 14.32 mL 28.63 mL
5 mM 0.57 mL 2.86 mL 5.73 mL
10 mM 0.29 mL 1.43 mL 2.86 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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References

References are publications that support the biological activity of the product.

Bosch et al (1998) Calmodulin inhibitor W13 induces sustained activation of ERK2 and expression of p21cip1. J.Biol.Chem. 273 22145 PMID: 9705360

Hidaka and Tanaka (1983) Naphthalenesulfonamides as calmodulin antagonists. Methods Enzymol. 102 185 PMID: 6139736

Stroble and Peterson (1992) Tamoxifen-resistant human breast cancer cell growth: inhibition by thionidazine, pim. and the calmodulin antagonist, W-13. J.Pharmacol.Exp.Ther. 263 186 PMID: 1403784


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Keywords: W-13 hydrochloride, W-13 hydrochloride supplier, Calmodulin, antagonists, Ca2+, Binding, Protein, modulators, Calcium, Signaling, Signalling, W13, 0361, Tocris Bioscience

2 Citations for W-13 hydrochloride

Citations are publications that use Tocris products. Selected citations for W-13 hydrochloride include:

Yanda et al (2017) Histone deacetylase 6 inhibition reduces cysts by decreasing cAMP and Ca(2+) in knock-out mouse models of polycystic kidney disease. J Biol Chem 292 17897 PMID: 28887310

Sethna et al (2016) Calmodulin activity regulates group I metabotropic glutamate receptor-mediated signal transduction and synaptic depression. J Neurosci Res 94 401 PMID: 26864654


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Reviews for W-13 hydrochloride

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PN and PH cells were treated with W-7 (catalog no. 0369) and W-13 (catalog no. 0361) purchased from Tocris..
By Anonymous on 11/17/2019
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: PN and PH cells

PN and PH cells were treated with W-7 (catalog no. 0369) and W-13(catalog no. 0361) purchased from Tocris.

PMID: 28887310
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