W-13 hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 0361 - W-13 hydrochloride | C14H17ClN2O2S.HCl | CAS No. 88519-57-7
Description: Calmodulin antagonist
Chemical Name: N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations

Biological Activity

Calmodulin antagonist (inhibits calmodulin activated PDE activity with an IC50 of 68 μM). Inhibits growth of tamoxifen-resistant breast cancer cells.

Technical Data

M. Wt 349.27
Formula C14H17ClN2O2S.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 88519-57-7
PubChem ID 16760706
InChI Key QKAALLVQBOLELJ-UHFFFAOYSA-N
Smiles Cl.NCCCCNS(=O)(=O)C1=CC=C2C(Cl)=CC=CC2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.93 100
water 34.93 100

Preparing Stock Solutions

The following data is based on the product molecular weight 349.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.86 mL 14.32 mL 28.63 mL
5 mM 0.57 mL 2.86 mL 5.73 mL
10 mM 0.29 mL 1.43 mL 2.86 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Bosch et al (1998) Calmodulin inhibitor W13 induces sustained activation of ERK2 and expression of p21cip1. J.Biol.Chem. 273 22145 PMID: 9705360

Hidaka and Tanaka (1983) Naphthalenesulfonamides as calmodulin antagonists. Methods Enzymol. 102 185 PMID: 6139736

Stroble and Peterson (1992) Tamoxifen-resistant human breast cancer cell growth: inhibition by thionidazine, pimozide and the calmodulin antagonist, W-13. J.Pharmacol.Exp.Ther. 263 186 PMID: 1403784


If you know of a relevant reference for W-13 hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Calcium Binding Protein Antagonists

Keywords: W-13 hydrochloride, supplier, Calmodulin, antagonists, Ca2+, Binding, Protein, modulators, Calcium, Signaling, Signalling, W13, Calcium, Binding, Protein, Calcium, Binding, Protein, Tocris Bioscience

Citations for W-13 hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for W-13 hydrochloride. Do you know of a great paper that uses W-13 hydrochloride from Tocris? If so please let us know.

W-13 hydrochloride Reviews

Average Rating:

(Based on 0 Reviews)


1 Star
0%
2 Star
0%
3 Star
0%
4 Star
0%
5 Star
0%

Have you used W-13 hydrochloride?

Submit a review and receive a $25US/€18/£15/$25CAN Amazon gift card if you include an image -$10US/€7/£6/$10CAN Amazon gift card for reviews without an image. Limited to verified customers in USA, Canada and Europe.