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W-12 hydrochloride

Cat. No. 0363 Submit a Review Datasheet / COA / SDS

Discontinued Product

W-12 hydrochloride (Cat. No. 0363) has been withdrawn from sale for commercial reasons.
Description: Calmodulin antagonist
Chemical Name: N-(4-Aminobutyl)-2-naphthalenesulfonamide hydrochloride
Datasheet
Citations
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Biological Activity Technical Data Datasheets References

Biological Activity for W-12 hydrochloride

Calmodulin antagonist; less active analogue of W-13 (0361). Inhibits calmodulin activated PDE activity with an IC50 of 260 μM.

Technical Data for W-12 hydrochloride

M. Wt 314.83
Storage Store at RT
CAS Number 89108-46-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for W-12 hydrochloride

Certificate of Analysis is currently unavailable on-line.
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Safety Datasheet

References for W-12 hydrochloride

References are publications that support the biological activity of the product.

Bosch et al (1998) Calmodulin inhibitor W13 induces sustained activation of ERK2 and expression of p21cip1. J.Biol.Chem. 273 22145 PMID: 9705360

Hidaka et al (1981) N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation. Proc.Natl.Acad.Sci.U.S.A. 78 4354 PMID: 6945588

Schofl et al (1999) Ca2+/calmodulin inhibition and phospholipase C-linked Ca2+ signaling in clonal β-cells. Endocrinology 140 5516 PMID: 10579314

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Citations for W-12 hydrochloride

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