W-12 hydrochloride

Discontinued Product

Unfortunately W-12 hydrochloride (Cat. No. 0363) has been withdrawn from sale for commercial reasons.
Cat.No. 0363 - W-12 hydrochloride | CAS No. 89108-46-3
Description: Calmodulin antagonist
Chemical Name: N-(4-Aminobutyl)-2-naphthalenesulfonamide hydrochloride

Biological Activity

Calmodulin antagonist; less active analogue of W-13 (0361). Inhibits calmodulin activated PDE activity with an IC50 of 260 μM.

Technical Data

M. Wt 314.83
Storage Store at RT
CAS Number 89108-46-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 314.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.18 mL 15.88 mL 31.76 mL
5 mM 0.64 mL 3.18 mL 6.35 mL
10 mM 0.32 mL 1.59 mL 3.18 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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Product Datasheets

Certificate of Analysis is currently unavailable
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Safety Datasheet


References are publications that support the products' biological activity.

Bosch et al (1998) Calmodulin inhibitor W13 induces sustained activation of ERK2 and expression of p21cip1. J.Biol.Chem. 273 22145 PMID: 9705360

Hidaka et al (1981) N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation. Proc.Natl.Acad.Sci.U.S.A. 78 4354 PMID: 6945588

Schofl et al (1999) Ca2+/calmodulin inhibition and phospholipase C-linked Ca2+ signaling in clonal β-cells. Endocrinology 140 5516 PMID: 10579314

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