Discontinued ProductW-12 hydrochloride (Cat. No. 0363) has been withdrawn from sale for commercial reasons.
Calmodulin antagonist; less active analogue of W-13 (0361). Inhibits calmodulin activated PDE activity with an IC50 of 260 μM.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Bosch et al (1998) Calmodulin inhibitor W13 induces sustained activation of ERK2 and expression of p21cip1. J.Biol.Chem. 273 22145 PMID: 9705360
Hidaka et al (1981) N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation. Proc.Natl.Acad.Sci.U.S.A. 78 4354 PMID: 6945588
Schofl et al (1999) Ca2+/calmodulin inhibition and phospholipase C-linked Ca2+ signaling in clonal β-cells. Endocrinology 140 5516 PMID: 10579314
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Keywords: W-12 hydrochloride, W-12 hydrochloride supplier, Calcium, Binding, Protein, 0363, Tocris Bioscience
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