Discontinued ProductUnfortunately W-12 hydrochloride (Cat. No. 0363) has been withdrawn from sale for commercial reasons.
Calmodulin antagonist; less active analogue of W-13 (0361). Inhibits calmodulin activated PDE activity with an IC50 of 260 μM.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 314.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.18 mL||15.88 mL||31.76 mL|
|5 mM||0.64 mL||3.18 mL||6.35 mL|
|10 mM||0.32 mL||1.59 mL||3.18 mL|
|50 mM||0.06 mL||0.32 mL||0.64 mL|
References are publications that support the products' biological activity.
Bosch et al (1998) Calmodulin inhibitor W13 induces sustained activation of ERK2 and expression of p21cip1. J.Biol.Chem. 273 22145 PMID: 9705360
Hidaka et al (1981) N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation. Proc.Natl.Acad.Sci.U.S.A. 78 4354 PMID: 6945588
Schofl et al (1999) Ca2+/calmodulin inhibition and phospholipase C-linked Ca2+ signaling in clonal β-cells. Endocrinology 140 5516 PMID: 10579314
View Related Products by Product Action
Keywords: W-12 hydrochloride, supplier, Calcium, Binding, Protein, Calcium, Binding, Protein, Tocris Bioscience
Citations for W-12 hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for W-12 hydrochloride.
Reviews for W-12 hydrochloride
There are currently no reviews for this product. Be the first to review W-12 hydrochloride and earn rewards!
Have you used W-12 hydrochloride?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and EuropeSubmit a Review