VX 680

Discontinued Product

VX 680 (Cat. No. 5907) has been withdrawn from sale for commercial reasons.
Description: High affinity and selective Aurora kinase inhibitor
Alternative Names: MK 0457,Tozasertib
Chemical Name: N-[4-[[4-(4-Methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for VX 680

VX 680 is a high affinity and selective Aurora kinase inhibitor (Ki values are 0.6, 5 and 18 nM for Aurora A, Aurora C and Aurora B, respectively). Also exhibits affinity for FLT-3 and Abl. Exhibits selectivity for Aurora kinase over 190 other protein kinases. Inhibits proliferation and induces apoptosis in a number of cancer cell lines in vitro. Reduces tumor size in leukemia and colon cancer cell xenografts in mice.

Technical Data for VX 680

M. Wt 464.59
Formula C23H28N8OS
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 639089-54-6
PubChem ID 5494449
Smiles CN1CCN(C2=NC(SC3=CC=C(C=C3)NC(C4CC4)=O)=NC(NC5=NNC(C)=C5)=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for VX 680

References are publications that support the biological activity of the product.

Bebbington et al (2009) The discovery of the potent aurora inhibitor MK-0457 (VX-680). Bioorg.Med.Chem.Lett. 19 3586 PMID: 19447622

Harrington et al (2004) VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nat.Med. 10 262 PMID: 14981513

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Keywords: VX 680, VX 680 supplier, VX680, MK0457, high, affinity, selective, aurora, kinases, inhibitors, inhibits, AurA, AurB, AurC, MK, 0457, Tozasertib, Aurora, Kinases, 5907, Tocris Bioscience

Citations for VX 680

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Currently there are no citations for VX 680.

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Literature in this Area

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