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Submit ReviewVX 680
Discontinued Product
VX 680 (Cat. No. 5907) has been withdrawn from sale for commercial reasons.
Description: High affinity and selective Aurora kinase inhibitor
Alternative Names: MK 0457, Tozasertib
Chemical Name: N-[4-[[4-(4-Methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide
Purity: ≥98% (HPLC)
Biological Activity for VX 680
VX 680 is a high affinity and selective Aurora kinase inhibitor (Ki values are 0.6, 5 and 18 nM for Aurora A, Aurora C and Aurora B, respectively). Also exhibits affinity for FLT-3 and Abl. Exhibits selectivity for Aurora kinase over 190 other protein kinases. Inhibits proliferation and induces apoptosis in a number of cancer cell lines in vitro. Reduces tumor size in leukemia and colon cancer cell xenografts in mice.
Technical Data for VX 680
| M. Wt | 464.59 |
| Formula | C23H28N8OS |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 639089-54-6 |
| PubChem ID | 5494449 |
| InChI Key | GCIKSSRWRFVXBI-UHFFFAOYSA-N |
| Smiles | CN1CCN(C2=NC(SC3=CC=C(C=C3)NC(C4CC4)=O)=NC(NC5=NNC(C)=C5)=C2)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for VX 680
References for VX 680
References are publications that support the biological activity of the product.
Bebbington et al (2009) The discovery of the potent aurora inhibitor MK-0457 (VX-680). Bioorg.Med.Chem.Lett. 19 3586 PMID: 19447622
Harrington et al (2004) VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nat.Med. 10 262 PMID: 14981513
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Keywords: VX 680, VX 680 supplier, VX680, MK0457, high, affinity, selective, aurora, kinases, inhibitors, inhibits, AurA, AurB, AurC, MK, 0457, Tozasertib, Aurora, Kinases, 5907, Tocris Bioscience
Citations for VX 680
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Currently there are no citations for VX 680.
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Literature in this Area
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Cancer Research Product Guide
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