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VX 680

Cat. No. 5907 COA / Product Datasheet SDS
Pricing Availability Delivery Time Qty
Cat.No. 5907 - VX 680 | C23H28N8OS | CAS No. 639089-54-6
Description: High affinity and selective Aurora kinase inhibitor
Alternative Names: MK 0457, Tozasertib
Chemical Name: N-[4-[[4-(4-Methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

High affinity and selective Aurora kinase inhibitor (Ki values are 0.6, 5 and 18 nM for Aurora A, Aurora C and Aurora B, respectively). Also exhibits affinity for FLT-3 and Abl. Exhibits selectivity for Aurora kinase over 190 other protein kinases. Inhibits proliferation and induces apoptosis in a number of cancer cell lines in vitro. Reduces tumor size in leukemia and colon cancer cell xenografts in mice.

Technical Data

M. Wt 464.59
Formula C23H28N8OS
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 639089-54-6
PubChem ID 5494449
InChI Key GCIKSSRWRFVXBI-UHFFFAOYSA-N
Smiles CN1CCN(C2=NC(SC3=CC=C(C=C3)NC(C4CC4)=O)=NC(NC5=NNC(C)=C5)=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.46 100

Preparing Stock Solutions

The following data is based on the product molecular weight 464.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.76 mL 21.52 mL
5 mM 0.43 mL 2.15 mL 4.3 mL
10 mM 0.22 mL 1.08 mL 2.15 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
Safety Datasheet

References

References are publications that support the products' biological activity.

Bebbington et al (2009) The discovery of the potent aurora inhibitor MK-0457 (VX-680). Bioorg.Med.Chem.Lett. 19 3586 PMID: 19447622

Harrington et al (2004) VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nat.Med. 10 262 PMID: 14981513

If you know of a relevant reference for VX 680, please let us know.

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Keywords: VX 680, supplier, VX680, MK0457, high, affinity, selective, aurora, kinases, inhibitors, inhibits, AurA, AurB, AurC, MK, 0457, Tozasertib, Aurora, Kinases, Aurora, Kinases, Tocris Bioscience

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