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Submit ReviewVUF 8430 dihydrobromide
Discontinued Product
2494 has been discontinued.
View all Histamine H<sub>4</sub> Receptors products.
Description: Potent and high affinity H4 agonist
Chemical Name: 2-[(Aminoiminomethyl)amino]ethyl carbamimidothioic acid ester dihydrobromide
Biological Activity for VUF 8430 dihydrobromide
VUF 8430 dihydrobromide is a high affinity (pKi = 7.5), potent histamine H4 receptor full agonist (pEC50 = 7.3). Displays moderate affinity for H3 receptors (pKi = 6.0) and weak partial agonist activity at H2 receptors.
Technical Data for VUF 8430 dihydrobromide
| M. Wt | 323.05 |
| Formula | C4H11N5S.2HBr |
| Storage | Desiccate at RT |
| CAS Number | 100130-32-3 |
| PubChem ID | 3063227 |
| InChI Key | GPWJSTKHQMIXCA-UHFFFAOYSA-N |
| Smiles | Br.Br.NC(SCCNC(N)=N)=N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for VUF 8430 dihydrobromide
References for VUF 8430 dihydrobromide
References are publications that support the biological activity of the product.
Sterk et al (1986) The influence of guanidio and isothiourea groups in histaminergic compounds on H2-activity. Agents Actions 18 137 PMID: 2942013
Lim et al (2006) Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist. J.Med.Chem. 49 6650 PMID: 17154494
Lim et al (2008) Phenylalanine 169 in the second extracellular loop of the human histamine H4 receptor is responsible for the difference in agonist binding between human and mouse H4 receptors. J.Pharmacol.Exp.Ther. 327 88 PMID: 18635748
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Keywords: VUF 8430 dihydrobromide, VUF 8430 dihydrobromide supplier, Potent, high, affinity, H4, agonists, Receptors, Histamine, histaminergic, VUF8430, dihydrobromide, 2494, Tocris Bioscience
1 Citation for VUF 8430 dihydrobromide
Citations are publications that use Tocris products. Selected citations for VUF 8430 dihydrobromide include:
Lamas et al (2014) Enhancement of ionizing radiation response by histamine in vitro and in vivo in human breast cancer. Cancer Biol Ther 16 137 PMID: 25482934
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.