Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewVUF 8430 dihydrobromide is a high affinity (pKi = 7.5), potent histamine H4 receptor full agonist (pEC50 = 7.3). Displays moderate affinity for H3 receptors (pKi = 6.0) and weak partial agonist activity at H2 receptors.
M. Wt | 323.05 |
Formula | C4H11N5S.2HBr |
Storage | Desiccate at RT |
CAS Number | 100130-32-3 |
PubChem ID | 3063227 |
InChI Key | GPWJSTKHQMIXCA-UHFFFAOYSA-N |
Smiles | Br.Br.NC(SCCNC(N)=N)=N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
water | 32.31 | 100 | |
DMSO | 32.31 | 100 |
The following data is based on the product molecular weight 323.05. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 3.1 mL | 15.48 mL | 30.95 mL |
5 mM | 0.62 mL | 3.1 mL | 6.19 mL |
10 mM | 0.31 mL | 1.55 mL | 3.1 mL |
50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
References are publications that support the biological activity of the product.
Sterk et al (1986) The influence of guanidio and isothiourea groups in histaminergic compounds on H2-activity. Agents Actions 18 137 PMID: 2942013
Lim et al (2006) Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist. J.Med.Chem. 49 6650 PMID: 17154494
Lim et al (2008) Phenylalanine 169 in the second extracellular loop of the human histamine H4 receptor is responsible for the difference in agonist binding between human and mouse H4 receptors. J.Pharmacol.Exp.Ther. 327 88 PMID: 18635748
If you know of a relevant reference for VUF 8430 dihydrobromide, please let us know.
Keywords: VUF 8430 dihydrobromide, VUF 8430 dihydrobromide supplier, Potent, high, affinity, H4, agonists, Receptors, Histamine, histaminergic, VUF8430, dihydrobromide, 2494, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for VUF 8430 dihydrobromide include:
Lamas et al (2014) Enhancement of ionizing radiation response by histamine in vitro and in vivo in human breast cancer. Cancer Biol Ther 16 137 PMID: 25482934
Do you know of a great paper that uses VUF 8430 dihydrobromide from Tocris? Please let us know.
There are currently no reviews for this product. Be the first to review VUF 8430 dihydrobromide and earn rewards!
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image