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Biological Activity for VUF 5574
VUF 5574 is a potent, selective, competitive antagonist for the human adenosine A3 receptor (Ki = 4 nM). Displays ≥ 2500-fold selectivity over A1 and A2A receptors.
Technical Data for VUF 5574
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for VUF 5574
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for VUF 5574
The following data is based on the product molecular weight 371.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.04 mM||67.31 mL||336.57 mL||673.15 mL|
|0.2 mM||13.46 mL||67.31 mL||134.63 mL|
|0.4 mM||6.73 mL||33.66 mL||67.31 mL|
|2 mM||1.35 mL||6.73 mL||13.46 mL|
References for VUF 5574
References are publications that support the biological activity of the product.
Baraldi and Borea (2000) New potent and selective human adenosine A3 receptor antagonists. TiPS 21 456 PMID: 11121831
van Muijlwijk-Koezen et al (2000) Isoquinoline and quinazoline urea analogues as antagonists for the human adenosine A3 receptor. J.Med.Chem. 43 2227 PMID: 10841801
If you know of a relevant reference for VUF 5574, please let us know.
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Keywords: VUF 5574, VUF 5574 supplier, Potent, selective, hA3, antagonists, Receptors, adenosines, VUF5574, Adenosine, A3, 1359, Tocris Bioscience
2 Citations for VUF 5574
Citations are publications that use Tocris products. Selected citations for VUF 5574 include:
Hua et al (2011) IL-4 amplifies the pro-inflammatory effect of adenosine in human mast cells by changing expression levels of adenosine receptors. PLoS One 6 e24947 PMID: 21966389
Pugliese et al (2006) A3 adenosine receptor antagonists delay irreversible synaptic failure caused by oxygen and glucose deprivation in the rat CA1 hippocampus in vitro. Br J Pharmacol 147 524 PMID: 16415905
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Literature in this Area
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