VUF 5574

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Cat.No. 1359 - VUF 5574 | C21H17N5O2 | CAS No. 280570-45-8
Description: Potent, selective hA3 antagonist
Chemical Name: N-(2-Methoxyphenyl)-N'-[2-(3-pyrindinyl)-4-quinazolinyl]-urea
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Potent, selective, competitive antagonist for the human adenosine A3 receptor (Ki = 4 nM). Displays ≥ 2500-fold selectivity over A1 and A2A receptors.

Technical Data

M. Wt 371.39
Formula C21H17N5O2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 280570-45-8
PubChem ID 4046493
InChI Key YRAFEJSZTVWUMD-UHFFFAOYSA-N
Smiles O=C(NC2=NC(C4=CC=CN=C4)=NC3=C2C=CC=C3)NC1=C(OC)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 1.49 4

Preparing Stock Solutions

The following data is based on the product molecular weight 371.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.69 mL 13.46 mL 26.93 mL
5 mM 0.54 mL 2.69 mL 5.39 mL
10 mM 0.27 mL 1.35 mL 2.69 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Baraldi and Borea (2000) New potent and selective human adenosine A3 receptor antagonists. TiPS 21 456 PMID: 11121831

van Muijlwijk-Koezen et al (2000) Isoquinoline and quinazoline urea analogues as antagonists for the human adenosine A3 receptor. J.Med.Chem. 43 2227 PMID: 10841801


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Keywords: VUF 5574, supplier, Potent, selective, hA3, antagonists, Receptors, adenosines, VUF5574, Adenosine, A3, Receptors, Adenosine, A3, Receptors, Tocris Bioscience

2 Citations for VUF 5574

Citations are publications that use Tocris products. Selected citations for VUF 5574 include:

Hua et al (2011) IL-4 amplifies the pro-inflammatory effect of adenosine in human mast cells by changing expression levels of adenosine receptors. PLoS One 6 e24947 PMID: 21966389

Pugliese et al (2006) A3 adenosine receptor antagonists delay irreversible synaptic failure caused by oxygen and glucose deprivation in the rat CA1 hippocampus in vitro. Br J Pharmacol 147 524 PMID: 16415905


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