VUF 11222

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Cat.No. 5668 - VUF 11222 | C25H31BrIN | CAS No. 1414376-84-3
Description: High affinity non-peptide CXCR3 agonist
Chemical Name: 2'-Bromo-N-[[(1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl]methyl]-N,N-dimethyl-[1,1'-biphenyl]-4-methanaminium iodide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

High affinity non-peptide CXCR3 agonist (pKi = 7.2).

Technical Data

M. Wt 552.33
Formula C25H31BrIN
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1414376-84-3
PubChem ID 71459294
InChI Key IXXWHYDKYNWDKJ-IUQUCOCYSA-M
Smiles C[N+](CC1=CC=C(C2=CC=CC=C2Br)C=C1)(C)CC3=CC[C@H]4C[C@@H]3C(C)4C.[I-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 5.52 10 with gentle warming
DMSO 55.23 100

Preparing Stock Solutions

The following data is based on the product molecular weight 552.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.81 mL 9.05 mL 18.11 mL
5 mM 0.36 mL 1.81 mL 3.62 mL
10 mM 0.18 mL 0.91 mL 1.81 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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References

References are publications that support the biological activity of the product.

Wijtmans et al (2012) Chemical subtleties in small-molecule modulation of peptide receptor function: the case of CXCR3 biaryl-type ligands. J.Med.Chem. 55 10572 PMID: 23150943


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Keywords: VUF 11222, VUF 11222 supplier, High, affinity, non-peptide, CXCR3, agonists, Chemokine, CXC, Receptors, 5668, Tocris Bioscience

Citations for VUF 11222

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