VUF 11222

Pricing Availability   Qty
Description: High affinity non-peptide CXCR3 agonist
Chemical Name: 2'-Bromo-N-[[(1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl]methyl]-N,N-dimethyl-[1,1'-biphenyl]-4-methanaminium iodide
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for VUF 11222

VUF 11222 is a high affinity non-peptide CXCR3 agonist (pKi = 7.2).

Technical Data for VUF 11222

M. Wt 552.33
Formula C25H31BrIN
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1414376-84-3
PubChem ID 71459294
Smiles C[N+](CC1=CC=C(C2=CC=CC=C2Br)C=C1)(C)CC3=CC[C@H]4C[C@@H]3C(C)4C.[I-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for VUF 11222

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 55.23 100
ethanol 5.52 10 with gentle warming

Preparing Stock Solutions for VUF 11222

The following data is based on the product molecular weight 552.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.81 mL 9.05 mL 18.11 mL
5 mM 0.36 mL 1.81 mL 3.62 mL
10 mM 0.18 mL 0.91 mL 1.81 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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References for VUF 11222

References are publications that support the biological activity of the product.

Wijtmans et al (2012) Chemical subtleties in small-molecule modulation of peptide receptor function: the case of CXCR3 biaryl-type ligands. J.Med.Chem. 55 10572 PMID: 23150943

If you know of a relevant reference for VUF 11222, please let us know.

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Keywords: VUF 11222, VUF 11222 supplier, High, affinity, non-peptide, CXCR3, agonists, Chemokine, CXC, Receptors, 5668, Tocris Bioscience

Citations for VUF 11222

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Literature in this Area

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