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VUF 11222 is a high affinity non-peptide CXCR3 agonist (pKi = 7.2).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||5.52||10 with gentle warming|
The following data is based on the product molecular weight 552.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.81 mL||9.05 mL||18.11 mL|
|5 mM||0.36 mL||1.81 mL||3.62 mL|
|10 mM||0.18 mL||0.91 mL||1.81 mL|
|50 mM||0.04 mL||0.18 mL||0.36 mL|
References are publications that support the biological activity of the product.
Wijtmans et al (2012) Chemical subtleties in small-molecule modulation of peptide receptor function: the case of CXCR3 biaryl-type ligands. J.Med.Chem. 55 10572 PMID: 23150943
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Keywords: VUF 11222, VUF 11222 supplier, High, affinity, non-peptide, CXCR3, agonists, Chemokine, CXC, Receptors, 5668, Tocris Bioscience
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.