VUF 10460

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Cat.No. 4769 - VUF 10460 | C15H19N5 | CAS No. 1028327-66-3
Description: Selective H4 agonist
Chemical Name: 4-(4-Methyl-1-piperazinyl)-6-phenyl-2-Pyrimidinamine
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective histamine H4 receptor agonist; displays 50-fold selectivity for the rat H4 receptor over the H3 subtype (pKi values are 5.75 and 7.46 for rat H3 and H4 receptors respectively). Also exhibits affinity for the human H4 receptor (pKi = 8.22).

Compound Libraries

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Technical Data

M. Wt 269.34
Formula C15H19N5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1028327-66-3
PubChem ID 25129523
InChI Key NIJGWJIOMPHDBP-UHFFFAOYSA-N
Smiles NC1=NC(C2=CC=CC=C2)=CC(N3CCN(C)CC3)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
2eq.HCl 26.93 100
DMSO 26.93 100
ethanol 26.93 100

Preparing Stock Solutions

The following data is based on the product molecular weight 269.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.71 mL 18.56 mL 37.13 mL
5 mM 0.74 mL 3.71 mL 7.43 mL
10 mM 0.37 mL 1.86 mL 3.71 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Altenbach et al (2008) Structure-activity studies on a series of a 2-aminopyrimidine-containing histamine H4 receptor ligands. J.Med.Chem. 51 6571 PMID: 18811133

Cowart et al (2008) Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models. J.Med.Chem. 51 6547 PMID: 18817367

Coruzzi et al (2011) Selective histamine H3 and H4 receptor agonists exert opposite effects against the gastric lesions induced by HCl in the rat stomach. Eur.J.Pharmacol. 669 121 PMID: 21839070


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Keywords: VUF10460 histamine histaminergic H4 receptors agonists selective Histamine H4 Receptors

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