VUF 10166

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Cat.No. 4532 - VUF 10166 | C13H15ClN4 | CAS No. 155584-74-0
Description: High affinity 5-HT3 antagonist
Chemical Name: 2-Chloro-3-(4-methyl-1-piperazinyl)quinoxaline
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity

High affinity 5-HT3 receptor antagonist (IC50 values are 0.04 and 22 nM for human 5HT3A and 5-HT3AB receptors respectively). Exhibits partial agonist activity at 5-HT3A receptors at higher concentrations (EC50 = 5.2 μM). Also histamine H4 receptor antagonist (pKi = 6.64 in HEK cells).

Technical Data

M. Wt 262.74
Formula C13H15ClN4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 155584-74-0
PubChem ID 24278976
InChI Key FFXVTQDGTKEXHF-UHFFFAOYSA-N
Smiles ClC2=NC1=CC=CC=C1N=C2N3CCN(C)CC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.27 100
ethanol 26.27 100

Preparing Stock Solutions

The following data is based on the product molecular weight 262.74. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.81 mL 19.03 mL 38.06 mL
5 mM 0.76 mL 3.81 mL 7.61 mL
10 mM 0.38 mL 1.9 mL 3.81 mL
50 mM 0.08 mL 0.38 mL 0.76 mL

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References

References are publications that support the biological activity of the product.

Thompson et al (2012) VUF10166, a novel compound with differing activities at 5-HT3A and 5-HT3AB receptors. J.Pharmacol.Exp.Ther. 341 350 PMID: 22306960

Smits et al (2008) Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo. J.Med.Chem. 51 2457 PMID: 18357976


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Ion Channel

Ion Channel Product Listing

A collection of around 500 products for ion channel research, the listing includes research tools for the study of:

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5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.