Home / Pharmacology / GPCRs / 7-TM Receptors / Acetylcholine Muscarinic Receptors / M4 Receptors / M4 Receptor Antagonists / VU 6028418 hydrochloride

VU 6028418 hydrochloride

Cat. No. 7658 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective M4 mAChR antagonist
Chemical Name: (3aR,5s,6aS)-2-((Tetrahydro-2H-pyran-4-yl)methyl)-N-(6-(2,3,5-trifluorophenyl)pyridazin-3-yl)octahydrocyclopenta[c]pyrrol-5-amine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for VU 6028418 hydrochloride

VU 6028418 hydrochloride is a potent and selective M4 mAChR antagonist (IC50 = 4.1 nM and 57 nM for human and rat M4 respectively). VU 6028418 hydrochloride dose-dependently reduces the latency to withdraw and reverses cataleptic behavior in haloperidol-treated animals. Orally bioavailable.

Licensing Information

Sold under license from Vanderbilt University

Technical Data for VU 6028418 hydrochloride

M. Wt 468.95
Formula C23H27F3N4O.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
InChI Key IQDWZBQDZTVTLN-NESBVOEXSA-N
Smiles [H][C@]12C[C@H](NC3=CC=C(C4=C(C(F)=CC(F)=C4)F)N=N3)C[C@]1(CN(C2)CC5CCOCC5)[H].Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for VU 6028418 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.9 100
ethanol 23.45 50

Preparing Stock Solutions for VU 6028418 hydrochloride

The following data is based on the product molecular weight 468.95. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.13 mL 10.66 mL 21.32 mL
5 mM 0.43 mL 2.13 mL 4.26 mL
10 mM 0.21 mL 1.07 mL 2.13 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for VU 6028418 hydrochloride

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for VU 6028418 hydrochloride

References are publications that support the biological activity of the product.

Spock et al (2021) Discovery of VU6028418: a highly selective and orally bioavailable M4 muscarinic acetylcholine receptor antagonist. ACS Med.Chem.Lett. 12 1342 PMID: 34413964

If you know of a relevant reference for VU 6028418 hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all M4 Receptor Antagonists

Keywords: VU 6028418 hydrochloride, VU 6028418 hydrochloride supplier, VU6028418, hydrochloride, potent, selective, Acetylcholine, Receptor, Cholinergic, Muscarinic, 4, antagonist, dystonia, mAChR, ACh, M4, Receptors, 7658, Tocris Bioscience

Citations for VU 6028418 hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for VU 6028418 hydrochloride. Do you know of a great paper that uses VU 6028418 hydrochloride from Tocris? Please let us know.

Reviews for VU 6028418 hydrochloride

There are currently no reviews for this product. Be the first to review VU 6028418 hydrochloride and earn rewards!

Have you used VU 6028418 hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.

Learning & Memory Poster

Learning & Memory Poster

Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.