VU 10010

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Description: Selective positive allosteric modulator of M4 receptors
Chemical Name: 3-Amino-N-[(4-chlorophenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)

Biological Activity for VU 10010

VU 10010 is a selective allosteric potentiator of M4 acetylcholine receptors (EC50 values are 33 and 0.7 nM for ACh in the absence and presence of VU10010 respectively). Binds to an allosteric site on the receptor increasing affinity for ACh and coupling to G-proteins.

Technical Data for VU 10010

M. Wt 345.85
Formula C17H16ClN3OS
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 633283-39-3
PubChem ID 714286
InChI Key FPRULFHDSFKYBV-UHFFFAOYSA-N
Smiles CC1=C2C(SC(C(NCC3=CC=C(Cl)C=C3)=O)=C2N)=NC(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for VU 10010

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.59 100
ethanol 3.46 10

Preparing Stock Solutions for VU 10010

The following data is based on the product molecular weight 345.85. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.89 mL 14.46 mL 28.91 mL
5 mM 0.58 mL 2.89 mL 5.78 mL
10 mM 0.29 mL 1.45 mL 2.89 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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References for VU 10010

References are publications that support the biological activity of the product.

Shirey et al (2008) An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission. Nat.Chem.Biol. 4 42 PMID: 18059262


If you know of a relevant reference for VU 10010, please let us know.

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Keywords: VU 10010, VU 10010 supplier, Selective, allosteric, potentiator, M4, receptors, Muscarinic, Receptors, Acetylcholine, ACh, VU10010, PAM, 3141, Tocris Bioscience

1 Citation for VU 10010

Citations are publications that use Tocris products. Selected citations for VU 10010 include:

Bell et al (2015) Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via α4β2* nicotinic receptor activation. PLoS One 9 115 PMID: 25918499


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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