VU 10010

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Cat.No. 3141 - VU 10010 | C17H16ClN3OS | CAS No. 633283-39-3
Description: Selective allosteric potentiator of M4 receptors
Chemical Name: 3-Amino-N-[(4-chlorophenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Selective allosteric potentiator of M4 acetylcholine receptors (EC50 values are 33 and 0.7 nM for ACh in the absence and presence of VU10010 respectively). Binds to an allosteric site on the receptor increasing affinity for ACh and coupling to G-proteins.

Compound Libraries

VU 10010 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 345.85
Formula C17H16ClN3OS
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 633283-39-3
PubChem ID 714286
InChI Key FPRULFHDSFKYBV-UHFFFAOYSA-N
Smiles CC1=C2C(SC(C(NCC3=CC=C(Cl)C=C3)=O)=C2N)=NC(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.59 100
ethanol 3.46 10

Preparing Stock Solutions

The following data is based on the product molecular weight 345.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.89 mL 14.46 mL 28.91 mL
5 mM 0.58 mL 2.89 mL 5.78 mL
10 mM 0.29 mL 1.45 mL 2.89 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Shirey et al (2008) An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission. Nat.Chem.Biol. 4 42 PMID: 18059262


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Keywords: VU 10010, supplier, Selective, allosteric, potentiator, M4, receptors, Muscarinic, Receptors, Acetylcholine, ACh, VU10010, M4, PAM, M4, Receptors, Tocris Bioscience

1 Citation for VU 10010

Citations are publications that use Tocris products. Selected citations for VU 10010 include:

Bell et al (2015) Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via ╬▒4╬▓2* nicotinic receptor activation. PLoS One 9 115 PMID: 25918499


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