VU 0546110

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Description: Selective SLO3 potassium channel inhibitor
Chemical Name: 1-[4-[[(4-Methoxyphenyl)thio]methyl]-1-piperidinyl]-2-[4-[(1-methylethyl)sulfonyl]phenyl]ethanone
Purity: ≥98% (HPLC)

Biological Activity for VU 0546110

VU 0546110 is a selective inhibitor of the sperm-specific potassium channel SLO3 (IC50 = 64 μM). It shows 40-fold selectivity over SLO1. It completely blocks heterologous SLO3 currents and endogenous K+ currents. VU 0546110 inhibits sperm hyperpolarisation and prevents its hyperactivated mobility.

Technical Data for VU 0546110

M. Wt 461.64
Formula C24H31NO4S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1421523-00-3
PubChem ID 71800954
Smiles O=C(CC1=CC=C(S(=O)(C(C)C)=O)C=C1)N2CCC(CC2)CSC3=CC=C(C=C3)OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for VU 0546110

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 46.16 100
ethanol 23.08 50

Preparing Stock Solutions for VU 0546110

The following data is based on the product molecular weight 461.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.17 mL 10.83 mL 21.66 mL
5 mM 0.43 mL 2.17 mL 4.33 mL
10 mM 0.22 mL 1.08 mL 2.17 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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References for VU 0546110

References are publications that support the biological activity of the product.

Lyon et al (2023) A selective inhibitor of the sperm-specific potassium channel SLO3 impairs human sperm function. Proc.Natl.Acad.Sci.U.S.A. 120 e2212338120 PMID: 36649421

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Keywords: VU 0546110, VU 0546110 supplier, VU0546110, selective, potassium, channels, K+, currents, slo, channel, hyperpolarisation, Non-selective, /, Other, Potassium, Channels, 7956, Tocris Bioscience

Citations for VU 0546110

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