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Submit ReviewVU 0467485 is a potent and selective positive allosteric modulator of M4 receptor; potentiates activity of ACh at M4 (EC50 values are 26.6 and 78.8 nM at rat and human M4 receptors, respectively). Exhibits selectivity for M4 over human and rat M1-3, 5, and a panel of 200 other pharmacological targets. Displays efficacy in a rat model of antipsychotic activity. Orally bioavailable and brain penetrant.
Sold under license from Vanderbilt University.
M. Wt | 360.41 |
Formula | C17H17FN4O2S |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
CAS Number | 1451994-10-7 |
PubChem ID | 89777239 |
InChI Key | VFNHDIWHQGVWLL-UHFFFAOYSA-N |
Smiles | COC1=C(C=C(C=C1)CNC(C2=C(C3=C(C(C)=NN=C3S2)C)N)=O)F |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 7.21 | 20 |
The following data is based on the product molecular weight 360.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.2 mM | 13.87 mL | 69.37 mL | 138.73 mL |
1 mM | 2.77 mL | 13.87 mL | 27.75 mL |
2 mM | 1.39 mL | 6.94 mL | 13.87 mL |
10 mM | 0.28 mL | 1.39 mL | 2.77 mL |
References are publications that support the biological activity of the product.
Wood et al (2016) Discovery of VU0467485/AZ13713945: an M4 PAM evaluated as a preclinical candidate for the treatment of schizophrenia. ACS Med.Chem.Lett. 8 233 PMID: 28197318
If you know of a relevant reference for VU 0467485, please let us know.
Keywords: VU 0467485, VU 0467485 supplier, VU0467485, positive, allosteric, modulators, selective, acetycholine, muscarinic, receptors, M4, antipsychotic, orally, bioavailable, Receptors, 6932, Tocris Bioscience
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Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.