Orally active α-glucosidase inhibitor (IC50 values are 3.9 and 6.4 nM at sucrase and maltase respectively). Increases glucagon-like peptide 1 (GLP-1) secretion and decreases food consumption in ob/ob mice, and reduces plasma concentrations of glucose, triglycerides and insulin in Wistar fatty rats. Exhibits antidiabetic and antiobesity activity in vivo.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 267.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.74 mL||18.71 mL||37.41 mL|
|5 mM||0.75 mL||3.74 mL||7.48 mL|
|10 mM||0.37 mL||1.87 mL||3.74 mL|
|50 mM||0.07 mL||0.37 mL||0.75 mL|
References are publications that support the products' biological activity.
Matsuo et al (1992) Effect of an intestinal disaccharidase inhibitor (AO-128) on obesity and diabetes. Am.J.Clin.Nutr. 55 314S PMID: 1728846
Matsui et al (2009) α-Glucosidase inhibition assay in an enzyme-immobilized amino-microplate. Anal.Sci. 25 559 PMID: 19359799
Moritoh et al (2009) Chronic administration of voglibose, an α-glucosidase inhibitor, increases active glucagon-like peptide-1 levels by increasing its secretion and decreasing dipeptidyl peptidase-4 activity in ob/ob mice. J.Pharmacol.Exp.Ther. 329 669 PMID: 19208898
If you know of a relevant reference for Voglibose, please let us know.
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Keywords: Voglibose, supplier, Orally, active, α-glucosidase, alpha-glucosidase, inhibitors, inhibits, Glycosylases, Glycosylases, Glycosylases, Tocris Bioscience
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