Voglibose

Pricing Availability Delivery Time Qty
Cat.No. 3596 - Voglibose | C10H21NO7 | CAS No. 83480-29-9
Description: Orally active α-glucosidase inhibitor
Chemical Name: 3,4-Dideoxy-4-[[2-hydroxy-1-(hydroxymethyl)ethyl]amino]-2-C-(hydroxymethyl)-D-epi-inositol
Datasheet
Citations
Reviews
Literature

Biological Activity

Orally active α-glucosidase inhibitor (IC50 values are 3.9 and 6.4 nM at sucrase and maltase respectively). Increases glucagon-like peptide 1 (GLP-1) secretion and decreases food consumption in ob/ob mice, and reduces plasma concentrations of glucose, triglycerides and insulin in Wistar fatty rats. Exhibits antidiabetic and antiobesity activity in vivo.

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Technical Data

M. Wt 267.28
Formula C10H21NO7
Storage Store at -20°C
CAS Number 83480-29-9
PubChem ID 444020
InChI Key FZNCGRZWXLXZSZ-CIQUZCHMSA-N
Smiles O[C@@H]1[C@](CO)(O)C[C@H](NC(CO)CO)[C@H](O)[C@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.05 75
water 26.73 100

Preparing Stock Solutions

The following data is based on the product molecular weight 267.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.74 mL 18.71 mL 37.41 mL
5 mM 0.75 mL 3.74 mL 7.48 mL
10 mM 0.37 mL 1.87 mL 3.74 mL
50 mM 0.07 mL 0.37 mL 0.75 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Matsuo et al (1992) Effect of an intestinal disaccharidase inhibitor (AO-128) on obesity and diabetes. Am.J.Clin.Nutr. 55 314S PMID: 1728846

Matsui et al (2009) α-Glucosidase inhibition assay in an enzyme-immobilized amino-microplate. Anal.Sci. 25 559 PMID: 19359799

Moritoh et al (2009) Chronic administration of voglibose, an α-glucosidase inhibitor, increases active glucagon-like peptide-1 levels by increasing its secretion and decreasing dipeptidyl peptidase-4 activity in ob/ob mice. J.Pharmacol.Exp.Ther. 329 669 PMID: 19208898


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Keywords: Voglibose, supplier, Orally, active, α-glucosidase, alpha-glucosidase, inhibitors, inhibits, Glycosylases, Glycosylases, Glycosylases, Tocris Bioscience

Citations for Voglibose

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