Voglibose

Discontinued Product

Voglibose (Cat. No. 3596) has been withdrawn from sale for commercial reasons.
Description: Orally active α-glucosidase inhibitor
Chemical Name: 3,4-Dideoxy-4-[[2-hydroxy-1-(hydroxymethyl)ethyl]amino]-2-C-(hydroxymethyl)-D-epi-inositol
Datasheet
Citations
Reviews

Biological Activity for Voglibose

Voglibose is an orally active α-glucosidase inhibitor (IC50 values are 3.9 and 6.4 nM at sucrase and maltase respectively). Increases glucagon-like peptide 1 (GLP-1) secretion and decreases food consumption in ob/ob mice, and reduces plasma concentrations of glucose, triglycerides and insulin in Wistar fatty rats. Exhibits antidiabetic and antiobesity activity in vivo.

Technical Data for Voglibose

M. Wt 267.28
Formula C10H21NO7
Storage Store at -20°C
CAS Number 83480-29-9
PubChem ID 444020
InChI Key FZNCGRZWXLXZSZ-CIQUZCHMSA-N
Smiles O[C@@H]1[C@](CO)(O)C[C@H](NC(CO)CO)[C@H](O)[C@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Voglibose

References are publications that support the biological activity of the product.

Matsuo et al (1992) Effect of an intestinal disaccharidase inhibitor (AO-128) on obesity and diabetes. Am.J.Clin.Nutr. 55 314S PMID: 1728846

Matsui et al (2009) α-Glucosidase inhibition assay in an enzyme-immobilized amino-microplate. Anal.Sci. 25 559 PMID: 19359799

Moritoh et al (2009) Chronic administration of voglibose, an α-glucosidase inhibitor, increases active glucagon-like peptide-1 levels by increasing its secretion and decreasing dipeptidyl peptidase-4 activity in ob/ob mice. J.Pharmacol.Exp.Ther. 329 669 PMID: 19208898

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Keywords: Voglibose, Voglibose supplier, Orally, active, α-glucosidase, alpha-glucosidase, inhibitors, inhibits, Glycosylases, 3596, Tocris Bioscience

Citations for Voglibose

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