VH 032 - linker 6

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Cat.No. 6684 - VH 032 - linker 6 | C31H42N4O7S | CAS No. 2098799-80-3
Description: VH 032-PEG2-alkyne
Chemical Name: (2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-6,9,12-trioxa-3-azapentadec-14-yn-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus PEG2 linker with terminal alkyne ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

Technical Data

M. Wt 614.75
Formula C31H42N4O7S
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2098799-80-3
PubChem ID 132045744
InChI Key HHXQNDSXTCIWSG-CERRFVOPSA-N
Smiles CC1=C(C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(COCCOCCOCC#C)=O)=O)O)=O)SC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 61.48 100
DMF 61.48 100

Preparing Stock Solutions

The following data is based on the product molecular weight 614.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.63 mL 8.13 mL 16.27 mL
5 mM 0.33 mL 1.63 mL 3.25 mL
10 mM 0.16 mL 0.81 mL 1.63 mL
50 mM 0.03 mL 0.16 mL 0.33 mL

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References

References are publications that support the biological activity of the product.

Zengerle et al (2015) Selective small molecule induced degradation of the BET bromodomain protein BRD4. ACS Chem.Biol. 10 1770 PMID: 26035625

Salami et al (2017) Waste disposal-An attractive strategy for cancer therapy. Science 355 1163 PMID: 28302825


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New Product Guide

New Product Guide (Fall/Winter 2018/2019)

Our new product guide highlights over 190 new products added to the Tocris Bioscience range during the second half of 2018.

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