VH 032 - linker 2New
Functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus a PEG linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 700.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.43 mL||7.14 mL||14.28 mL|
|5 mM||0.29 mL||1.43 mL||2.86 mL|
|10 mM||0.14 mL||0.71 mL||1.43 mL|
|50 mM||0.03 mL||0.14 mL||0.29 mL|
References are publications that support the biological activity of the product.
Salami et al (2017) Waste disposal-An attractive strategy for cancer therapy. Science 355 1163 PMID: 28302825
Zengerle et al (2015) Selective small molecule induced degradation of the BET bromodomain protein BRD4. ACS Chem.Biol. 10 1770 PMID: 26035625
Chan et al (2018) Impact of target warhead and linkage vector on inducing protein degradation: comparison of bromodomain and extra-terminal (BET) degraders derived from triazolodiazepine (JQ1) and tetrahydroquinoline (I-BET726) BET inhibitor scaffolds. J.Med.Chem. 61 504 PMID: 28595007
If you know of a relevant reference for VH 032 - linker 2, please let us know.
Keywords: VH 032 - linker 2, VH 032 - linker 2 supplier, Proteolysis, Targeting, Chimera, PROTACs, VHL, E3, ubiquitin, ligase, PEG, linker, conjugate, PROTAC, polyethene, glycol, von-Hippel-Lindau, protein, ligand, VH032, -, 2, Tools, for, R&D, 6464, Tocris Bioscience
Citations for VH 032 - linker 2
Citations are publications that use Tocris products.
Currently there are no citations for VH 032 - linker 2. Do you know of a great paper that uses VH 032 - linker 2 from Tocris? Please let us know.
Reviews for VH 032 - linker 2
There are currently no reviews for this product. Be the first to review VH 032 - linker 2 and earn rewards!
Have you used VH 032 - linker 2?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and EuropeSubmit a Review
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide (Spring/Summer 2018)New
Our new product guide highlights over 200 new products added to the Tocris Bioscience range during the second half of 2017.
- 7-TM Receptors
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Cell Metabolism
- Fluorescent Imaging
- Signal Transduction
- Stem Cells