VH 032 - linker 2

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Cat.No. 6464 - VH 032 - linker 2 | C32H49N5O8S.HCl | CAS No. 2064292-52-8
Description: VH 032-PEG4-amine
Chemical Name: (2S,4R)-1-((S)-17-amino-2-(tert-butyl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
Purity: ≥95% (HPLC)

Biological Activity

Functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus a PEG linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

Technical Data

M. Wt 700.29
Formula C32H49N5O8S.HCl
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2064292-52-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 70.03 100
DMSO 70.03 100

Preparing Stock Solutions

The following data is based on the product molecular weight 700.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.43 mL 7.14 mL 14.28 mL
5 mM 0.29 mL 1.43 mL 2.86 mL
10 mM 0.14 mL 0.71 mL 1.43 mL
50 mM 0.03 mL 0.14 mL 0.29 mL

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References are publications that support the biological activity of the product.

Salami et al (2017) Waste disposal-An attractive strategy for cancer therapy. Science 355 1163 PMID: 28302825

Zengerle et al (2015) Selective small molecule induced degradation of the BET bromodomain protein BRD4. ACS Chem.Biol. 10 1770 PMID: 26035625

Chan et al (2018) Impact of target warhead and linkage vector on inducing protein degradation: comparison of bromodomain and extra-terminal (BET) degraders derived from triazolodiazepine (JQ1) and tetrahydroquinoline (I-BET726) BET inhibitor scaffolds. J.Med.Chem. 61 504 PMID: 28595007

If you know of a relevant reference for VH 032 - linker 2, please let us know.

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