VH 032 - linker 1

Pricing Availability Delivery Time Qty
Cat.No. 6463 - VH 032 - linker 1 | C30H45N5O7S.HCl | CAS No. 2097971-11-2
Description: Functionalized VHL ligand for PROTACs; incorporates an E3 ligase ligand plus a PEG linker
Chemical Name: (2S,4R)-1-((S)-14-amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
Purity: ≥95% (HPLC)
Datasheet
Citations
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Literature

Biological Activity

Functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus a PEG linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

Technical Data

M. Wt 656.23
Formula C30H45N5O7S.HCl
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2097971-11-2
Smiles NCCOCCOCCOCC(N[C@H](C(N1C[C@H](O)C[C@H]1C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)=O)C(C)(C)C)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 65.62 100
water 65.62 100

Preparing Stock Solutions

The following data is based on the product molecular weight 656.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.52 mL 7.62 mL 15.24 mL
5 mM 0.3 mL 1.52 mL 3.05 mL
10 mM 0.15 mL 0.76 mL 1.52 mL
50 mM 0.03 mL 0.15 mL 0.3 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Zengerle et al (2015) Selective small molecule induced degradation of the BET bromodomain protein BRD4. ACS Chem. Biol. 10 1770 PMID: 26035625

Salami et al (2017) Waste disposal-An attractive strategy for cancer therapy. Science 355 1163 PMID: 28302825


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Citations for VH 032 - linker 1

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