Vandetanib

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Cat.No. 7497 - Vandetanib | C22H24BrFN4O2 | CAS No. 443913-73-3
Description: Potent VEGFR-2 inhibitor, also inhibits EGFR and RET oncoproteins activity
Chemical Name: N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)
Pathways (1)

Biological Activity for Vandetanib

Vandetanib is a potent VEGFR-2 inhibitor (IC50 = 0.04 μM), and inhibitor of EGFR (IC50 = 0.5 μM). Vandetanib potently inhibits (IC50 = 100 nM) RET oncoprotein activity in human thyroid cancer. Vandetanib displays anti-angiogenic properties in human nasopharyngeal carcinoma in mice model. Vandetanib is orally available and effective in vivo.

Technical Data for Vandetanib

M. Wt 475.36
Formula C22H24BrFN4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 443913-73-3
PubChem ID 3081361
InChI Key UHTHHESEBZOYNR-UHFFFAOYSA-N
Smiles FC1=CC(Br)=CC=C1NC=2N=CN=C3C=C(OCC4CCN(C)CC4)C(OC)=CC32

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Vandetanib

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.77 50

Preparing Stock Solutions for Vandetanib

The following data is based on the product molecular weight 475.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.21 mL 21.04 mL 42.07 mL
2.5 mM 0.84 mL 4.21 mL 8.41 mL
5 mM 0.42 mL 2.1 mL 4.21 mL
25 mM 0.08 mL 0.42 mL 0.84 mL

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References for Vandetanib

References are publications that support the biological activity of the product.

Carlomagno et al (2002) ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases. Cancer res. 62 7284 PMID: 12499271

Cui et al (2015) Resonance imaging for monitoring the early response to ZD6474 from nasopharyngeal carcinoma in nude mouse. Sci.Rep. 5 16389 PMID: 26574153

Ancker et al (2019) Multikinase inhibitor treatment in thyroid cancer. Int.J.Mol.Sci. 21 10 PMID: 31861373

Hennequin et al (2002) Novel 4-anilinoquinazolines with C-7 basic side chains: design and structure activity relationship of a series of potent, orally active, VEGF receptor tyrosine kinase inhibitors. J.Med.Chem. 45 1300 PMID: 11881999


If you know of a relevant reference for Vandetanib, please let us know.

View Related Products by Product Action

View all VEGFR Inhibitors

Keywords: Vandetanib, Vandetanib supplier, Potent, inhibitors, inhibits, VEGFR-2, Vascular, Endothelial, Growth, Factors, Receptors, KDR, Flk1, EGFR, epidermal, growth, factor, receptor, anticancer, RET, VEGFR, 7497, Tocris Bioscience

Citations for Vandetanib

Citations are publications that use Tocris products.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases Product Listing

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for Vandetanib

VEGF Signaling Pathway

VEGF Signaling Pathway

VEGF signaling pathway is involved in embryonic vascular development (vasculogenesis) and in the formation of new blood vessel (angiogenesis). It also induces cell migration, proliferation and survival.