Urotensin II-related peptide
Discontinued Product
Urotensin II-related peptide (Cat. No. 2215) has been withdrawn from sale for commercial reasons.
Biological Activity
Potent endogenous agonist for the urotensin-II (UT) receptor. Binds with high affinity and potently activates recombinant rat and human UT receptors (EC50 values are 0.55 and 4.8 nM respectively). Produces hypotensive effects following systemic administration in rats.
Technical Data
| M. Wt | 1017.23 |
| Formula | C49H64N10O10S2 |
| Sequence |
ACFWKYCV (Modifications: Disulfide bridge between 2 - 7) |
| Storage | Desiccate at -20°C |
| CAS Number | 342878-90-4 |
| Smiles | [H]N[C@@H](C)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC1=O)C(=O)N[C@@H](C(C)C)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Product Datasheets
References
References are publications that support the biological activity of the product.
Mori and Fujino (2004) Urotensin II-related peptide, the endogenous ligand for the urotensin II receptor in the rat brain. Peptides 25 1815 PMID: 15476951
Chatenet et al (2004) Structure-activity relationships and structural conformation of a novel urotensin II-related peptide. Peptides 25 1819 PMID: 15476952
Sugo et al (2003) Identification of urotensin II-related peptide as the urotensin II-immunoreactive molecule in the rat brain. Biochem.Biophys.Res.Comm. 310 860
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Keywords: Urotensin II-related peptide, Urotensin II-related peptide supplier, Endogenous, urotensin, II, receptor, agonists, UT, Receptors, Urotensin-II, 2215, Tocris Bioscience
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Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.
