Urotensin II-related peptide
Discontinued Product
Unfortunately Urotensin II-related peptide (Cat. No. 2215) has been withdrawn from sale for commercial reasons.
Biological Activity
Potent endogenous agonist for the urotensin-II (UT) receptor. Binds with high affinity and potently activates recombinant rat and human UT receptors (EC50 values are 0.55 and 4.8 nM respectively). Produces hypotensive effects following systemic administration in rats.
Technical Data
| M. Wt | 1017.23 |
| Formula | C49H64N10O10S2 |
| Sequence |
ACFWKYCV (Modifications: Disulfide bridge between 2 - 7) |
| Storage | Desiccate at -20°C |
| CAS Number | 342878-90-4 |
| Smiles | [H]N[C@@H](C)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC1=O)C(=O)N[C@@H](C(C)C)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 1017.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.98 mL | 4.92 mL | 9.83 mL |
| 5 mM | 0.2 mL | 0.98 mL | 1.97 mL |
| 10 mM | 0.1 mL | 0.49 mL | 0.98 mL |
| 50 mM | 0.02 mL | 0.1 mL | 0.2 mL |
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References
References are publications that support the products' biological activity.
Mori and Fujino (2004) Urotensin II-related peptide, the endogenous ligand for the urotensin II receptor in the rat brain. Peptides 25 1815 PMID: 15476951
Chatenet et al (2004) Structure-activity relationships and structural conformation of a novel urotensin II-related peptide. Peptides 25 1819 PMID: 15476952
Sugo et al (2003) Identification of urotensin II-related peptide as the urotensin II-immunoreactive molecule in the rat brain. Biochem.Biophys.Res.Comm. 310 860 PMID:
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Keywords: Urotensin II-related peptide, supplier, Endogenous, urotensin, II, receptor, agonists, UT, Receptors, Urotensin-II, Urotensin-II, Receptors, Tocris Bioscience
Citations for Urotensin II-related peptide
Citations are publications that use Tocris products.
Currently there are no citations for Urotensin II-related peptide.
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