Urotensin II-related peptide

Discontinued Product

Unfortunately Urotensin II-related peptide (Cat. No. 2215) has been withdrawn from sale for commercial reasons.
Cat.No. 2215 - Urotensin II-related peptide | Ala-Cys-Phe-Trp-Lys-Tyr-Cys-Val (Disulfide bridge: 2 - 7) | CAS No. 342878-90-4
Description: Endogenous urotensin-II receptor agonist
Datasheet
Citations
Literature

Biological Activity

Potent endogenous agonist for the urotensin-II (UT) receptor. Binds with high affinity and potently activates recombinant rat and human UT receptors (EC50 values are 0.55 and 4.8 nM respectively). Produces hypotensive effects following systemic administration in rats.

Technical Data

M. Wt 1017.23
Formula C49H64N10O10S2
Sequence ACFWKYCV

(Modifications: Disulfide bridge between 2 - 7)

Storage Desiccate at -20°C
CAS Number 342878-90-4
Smiles [H]N[C@@H](C)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC1=O)C(=O)N[C@@H](C(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 1017.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.98 mL 4.92 mL 9.83 mL
5 mM 0.2 mL 0.98 mL 1.97 mL
10 mM 0.1 mL 0.49 mL 0.98 mL
50 mM 0.02 mL 0.1 mL 0.2 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Mori and Fujino (2004) Urotensin II-related peptide, the endogenous ligand for the urotensin II receptor in the rat brain. Peptides 25 1815 PMID: 15476951

Chatenet et al (2004) Structure-activity relationships and structural conformation of a novel urotensin II-related peptide. Peptides 25 1819 PMID: 15476952

Sugo et al (2003) Identification of urotensin II-related peptide as the urotensin II-immunoreactive molecule in the rat brain. Biochem.Biophys.Res.Comm. 310 860 PMID:

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Keywords: Endogenous urotensin II receptor agonists UT Receptors Urotensin-II Urotensin-II Receptors

Citations for Urotensin II-related peptide

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Literature in this Area

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Pathways for Urotensin II-related peptide

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