Urotensin II (human)

Pricing Availability   Qty
Cat.No. 1642 - Urotensin II (human) | Glu-Thr-Pro-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val (Disulfide bridge: 5 - 10) | CAS No. 251293-28-4
Description: Endogenous vasoactive agonist for the UT receptor
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent endogenous peptide agonist for the urotensin-II receptor (EC50 = 0.1 nM). Displays arterio-selective vasoconstriction and vasodilatation in mammals in vitro and in vivo, effects which vary between species. Also has been shown to mediate bronchoconstriction.

Technical Data

M. Wt 1388.57
Formula C64H85N13O18S2
Sequence ETPDCFWKYCV

(Modifications: Disulfide bridge between 5 - 10)

Storage Desiccate at -20°C
CAS Number 251293-28-4
PubChem ID 46225600
InChI Key HFNHAPQMXICKCF-USJMABIRSA-N
Smiles [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC1=O)C(=O)N[C@@H](C(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Coulouarn et al (1998) Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurones of the spinal cord. Proc.Natl.Acad.Sci.U.S.A. 95 15803 PMID: 9861051

Maguire and Davenport (2002) Is urotensin-II the new endothelin? Br.J.Pharmacol 137 579 PMID: 12381671

Nothacker et al (1999) Identification of the natural ligand of an orphan G-protein-coupled receptor involved in the regulation of vasoconstriction. Nat.Cell.Biol. 1 383 PMID: 10559967


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Keywords: Urotensin II (human), Urotensin II (human) supplier, Endogenous, vasoactive, agonists, UT, receptor, Receptors, Urotensin-II, UrotensinII, (human), 1642, Tocris Bioscience

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