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Cat.No. 5296 - Urantide | Asp-Pen-Phe-D-Trp-Orn-Tyr-Cys-Val | CAS No. 669089-53-6
Description: Selective and competitive urotensin II receptor antagonist
Alternative Names: [Pen5,DTrp7,Orn8]hU-II(4-11)
Literature (4)

Biological Activity

Selective and competitive urotensin-II (UT) receptor antagonist (pKB = 8.3). Blocks hU-II induced contractions in thoracic aorta ex vivo. Exhibits no effect on noradrenaline or endothelin 1-induced contraction or on acetylcholine-induced relaxation. Behaves as a partial agonist in a calcium mobilization assay (in CHO cells expressing hUT receptors).

Technical Data

M. Wt 1075.26
Formula C51H66N10O12S2
Sequence DXFWXYCV(Modifications: X-2 = Pen, X-5 = Orn, Trp-4 = D-Trp, Disulfide bridge: 2-7)

Storage Store at -20°C
CAS Number 669089-53-6
PubChem ID 11520939
Smiles CC(C)[C@H](NC(=O)[C@@H]1CSSC(C)(C)[C@@H](NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 2 mg/ml in water


References are publications that support the biological activity of the product.

Patacchini et al (2003) Urantide: an ultrapotent urotensin II antagonist peptide in the rat aorta. Br.J.Pharmacol. 140 1155 PMID: 14645137

Carotenuto et al (2014) Lead optimization of P5U and urantide: discovery of novel potent ligands at the urotensin-II receptor. J.Med.Chem. 57 5965 PMID: 24992374

If you know of a relevant reference for Urantide, please let us know.

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Keywords: Urantide, Urantide supplier, Selective, competitive, urotensin, II, antagonists, [Pen5,DTrp7,Orn8]hU-II(4-11), Urotensin-II, Receptors, 5296, Tocris Bioscience

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