UPF 648

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Cat.No. 4926 - UPF 648 | C11H8Cl2O3 | CAS No. 213400-34-1
Description: Potent kynurenine 3-monooxygenase (KMO) inhibitor
Chemical Name: (1S,2S)-2-(3,4-Dichlorobenzoyl)cyclopropanecarboxylic acid
Purity: ≥98% (HPLC)
Literature (7)

Biological Activity for UPF 648

UPF 648 is a potent kynurenine 3-monooxygenase (kynurenine 3-hydroxylase; KMO) inhibitor (IC50 = 20 nM). Increases kynurenic acid levels, and decreases 3-HK and QUIN levels in cerebrum and liver of neonatal rodents. Neuroprotective in a Drosophila model of Huntington's disease.

Technical Data for UPF 648

M. Wt 259.09
Formula C11H8Cl2O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 213400-34-1
PubChem ID 9859947
Smiles [H][C@]1([C@@H]([C@](O)=O)C1)C(C2=CC=C(Cl)C(Cl)=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for UPF 648

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 25.91 100

Preparing Stock Solutions for UPF 648

The following data is based on the product molecular weight 259.09. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.86 mL 19.3 mL 38.6 mL
5 mM 0.77 mL 3.86 mL 7.72 mL
10 mM 0.39 mL 1.93 mL 3.86 mL
50 mM 0.08 mL 0.39 mL 0.77 mL

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Product Datasheets for UPF 648

Certificate of Analysis / Product Datasheet
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References for UPF 648

References are publications that support the biological activity of the product.

Ceresoli-Borroni et al (2007) Perinatal kynurenine 3-hydroxylase inhibition in rodents: pathophysiological implications. J.Neurosci.Res. 85 845 PMID: 17279543

Amaral et al (2013) Structural basis of kynurenine 3-monooxygenase inhibition. Nature 496 382 PMID: 23575632

Amori et al (2009) On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo. J.Neurochem. 109 316 PMID: 19226371

Campesan et al (2011) The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease. Curr.Biol. 21 961 PMID: 21636279

If you know of a relevant reference for UPF 648, please let us know.

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Keywords: UPF 648, UPF 648 supplier, UPF648, potent, kynurenine, 3-monooxygenase, 3-hydroxylase, KMO, inhibitors, inhibits, huntington's, disease, KYNA, 3-hk, QUIN, neuroprotective, Hydroxylases, Kynurenine, 4926, Tocris Bioscience

Citations for UPF 648

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