You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
UNC 6852 New
Biological Activity for UNC 6852
UNC 6852 is a polycomb repressive complex 2 (PRC2) Degrader (PROTAC®; DC50 = 0.79 μM). It comprises an EED (embryonic ectoderm development) based ligand, joined by a linker to a von Hippel-Lindau ligand. In B lymphoblast cell lines, UNC 6852 selectively degrades PRC2 components EED (DC50 = 0.31 μM, Dmax = 94%), enhancer of zeste homolog 2 (EZH2, DC50 = 0.67 μM, Dmax = 96%), and suppressor of zeste homolog 12 (SUZ12, DC50 = 0.59 μM, Dmax = 82%). In zebrafish, UNC 6852 treatment increases transcription of tfpia and prolongs time to occlusion (TTO) in the caudal vein following laser injury.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Technical Data for UNC 6852
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for UNC 6852
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for UNC 6852
The following data is based on the product molecular weight 832.98. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.2 mL||6 mL||12.01 mL|
|5 mM||0.24 mL||1.2 mL||2.4 mL|
|10 mM||0.12 mL||0.6 mL||1.2 mL|
|50 mM||0.02 mL||0.12 mL||0.24 mL|
References for UNC 6852
References are publications that support the biological activity of the product.
Potjewyd et al (2020) Degradation of polycomb repressive complex 2 with an EED-targeted bivalent chemical degrader. Cell Chem.Biol. 27 47 PMID: 31831267
Raman et al (2021) Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Sci.Rep. 11 15238 PMID: 34315984
If you know of a relevant reference for UNC 6852, please let us know.
View Related Products by Target
Keywords: UNC 6852, UNC 6852 supplier, UNC6852, polycomb, repressive, complex, 2, PRC2, degraders, degrades, PROTAC, tissue, factor, pathway, tfpia, EZH2, EED, SUZ12, Active, Degraders, 7816, Tocris Bioscience
Citations for UNC 6852
Citations are publications that use Tocris products.
Currently there are no citations for UNC 6852. Do you know of a great paper that uses UNC 6852 from Tocris? Please let us know.
Reviews for UNC 6852
There are currently no reviews for this product. Be the first to review UNC 6852 and earn rewards!
Have you used UNC 6852?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Targeted Protein Degradation Research Product GuideUpdated
This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:
- Active Degraders
- TAG Degradation Platform
- Degrader Building Blocks
- Ubiquitin-Proteasome System Proteins
- Assays for Protein Degradation
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Epigenetics in Cancer Poster
This poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia