UNC 3866

Discontinued Product

UNC 3866 (Cat. No. 6096) has been withdrawn from sale for commercial reasons.
Description: High affinity CBX4 and CBX7 inhibitor
Chemical Name: N-[4-(1,1-Dimethylethyl)benzoyl]-L-phenylalanyl-L-alanyl-L-leucyl-N6,N6-diethyl-L-lysyl-L-serine methyl ester

Biological Activity for UNC 3866

High affinity CBX4 and CBX7 inhibitor (Ki values are 94 and 97 nM, respectively). Exhibits >6-fold selectivity for CBX4/7 over other CBX and CDY family members. Inhibits proliferation of PC3 cells in vitro.

External Portal Information for UNC 3866

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of UNC 3866 is reviewed on the chemical probes website.

Technical Data for UNC 3866

M. Wt 795.02
Formula C43H66N6O8
Storage Store at -20°C
CAS Number 1872382-47-2
PubChem ID 101043861
Smiles CCN(CCCC[C@@H](C(N[C@H](C(OC)=O)CO)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC(C1=CC=C(C(C)(C)C)C=C1)=O)CC2=CC=CC=C2)=O)C)=O)CC(C)C)=O)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for UNC 3866

References are publications that support the biological activity of the product.

Stuckey et al (2016) A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nat.Chem.Biol. 12 180 PMID: 26807715

Barnash et al (2016) Chromodomain ligand optimization via target-class directed combinatorial repurposing. ACS Chem.Biol. 11 2475 PMID: 27356154

Stuckey et al (2016) Structure-activity relationships and kinetic studies of peptidic antagonists of CBX chromodomains. J.Med.Chem. 59 8913 PMID: 27571219

Keywords: UNC 3866, UNC 3866 supplier, UNC3866, high, affinity, CBX4, CBX7, inhibitors, Other, Lysine, Methyltransferases, 6096, Tocris Bioscience

Citations for UNC 3866

Citations are publications that use Tocris products.

Currently there are no citations for UNC 3866.

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