UNC 3866

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Cat.No. 6096 - UNC 3866 | C43H66N6O8 | CAS No. 1872382-47-2
Description: High affinity CBX4 and CBX7 inhibitor
Chemical Name: N-[4-(1,1-Dimethylethyl)benzoyl]-L-phenylalanyl-L-alanyl-L-leucyl-N6,N6-diethyl-L-lysyl-L-serine methyl ester

Biological Activity

High affinity CBX4 and CBX7 inhibitor (Ki values are 94 and 97 nM, respectively). Exhibits >6-fold selectivity for CBX4/7 over other CBX and CDY family members. Inhibits proliferation of PC3 cells in vitro.

Technical Data

M. Wt 795.02
Formula C43H66N6O8
Storage Store at -20°C
CAS Number 1872382-47-2
PubChem ID 101043861
Smiles CCN(CCCC[C@@H](C(N[C@H](C(OC)=O)CO)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC(C1=CC=C(C(C)(C)C)C=C1)=O)CC2=CC=CC=C2)=O)C)=O)CC(C)C)=O)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 79.5 100
ethanol 15.9 20mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 795.02. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.26 mL 6.29 mL 12.58 mL
5 mM 0.25 mL 1.26 mL 2.52 mL
10 mM 0.13 mL 0.63 mL 1.26 mL
50 mM 0.03 mL 0.13 mL 0.25 mL

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Product Datasheets

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References are publications that support the products' biological activity.

Stuckey et al (2016) A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nat.Chem.Biol. 12 180 PMID: 26807715

Barnash et al (2016) Chromodomain ligand optimization via target-class directed combinatorial repurposing. ACS Chem.Biol. 11 2475 PMID: 27356154

Stuckey et al (2016) Structure-activity relationships and kinetic studies of peptidic antagonists of CBX chromodomains. J.Med.Chem. 59 8913 PMID: 27571219

If you know of a relevant reference for UNC 3866, please let us know.

Keywords: UNC 3866, supplier, UNC3866, high, affinity, CBX4, CBX7, inhibitors, Other, Lysine, Methyltransferases, Lysine, Methyltransferases, Other, Lysine, Methyltransferases, Tocris Bioscience

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