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High affinity CBX4 and CBX7 inhibitor (Ki values are 94 and 97 nM, respectively). Exhibits >6-fold selectivity for CBX4/7 over other CBX and CDY family members. Inhibits proliferation of PC3 cells in vitro.
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Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of UNC 3866 is reviewed on the chemical probes website.
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The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Stuckey et al (2016) A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nat.Chem.Biol. 12 180 PMID: 26807715
Barnash et al (2016) Chromodomain ligand optimization via target-class directed combinatorial repurposing. ACS Chem.Biol. 11 2475 PMID: 27356154
Stuckey et al (2016) Structure-activity relationships and kinetic studies of peptidic antagonists of CBX chromodomains. J.Med.Chem. 59 8913 PMID: 27571219
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Keywords: UNC 3866, UNC 3866 supplier, UNC3866, high, affinity, CBX4, CBX7, inhibitors, Other, Lysine, Methyltransferases, 6096, Tocris Bioscience
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