High affinity CBX4 and CBX7 inhibitor (Ki values are 94 and 97 nM, respectively). Exhibits >6-fold selectivity for CBX4/7 over other CBX and CDY family members. Inhibits proliferation of PC3 cells in vitro.
External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of UNC 3866 is reviewed on the chemical probes website.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||15.9||20 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 795.02. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.26 mL||6.29 mL||12.58 mL|
|5 mM||0.25 mL||1.26 mL||2.52 mL|
|10 mM||0.13 mL||0.63 mL||1.26 mL|
|50 mM||0.03 mL||0.13 mL||0.25 mL|
References are publications that support the biological activity of the product.
Stuckey et al (2016) A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nat.Chem.Biol. 12 180 PMID: 26807715
Barnash et al (2016) Chromodomain ligand optimization via target-class directed combinatorial repurposing. ACS Chem.Biol. 11 2475 PMID: 27356154
Stuckey et al (2016) Structure-activity relationships and kinetic studies of peptidic antagonists of CBX chromodomains. J.Med.Chem. 59 8913 PMID: 27571219
If you know of a relevant reference for UNC 3866, please let us know.
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Keywords: UNC 3866, UNC 3866 supplier, UNC3866, high, affinity, CBX4, CBX7, inhibitors, Other, Lysine, Methyltransferases, 6096, Tocris Bioscience
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