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Biological Activity for UNC 2881
UNC 2881 is a potent Mer kinase inhibitor. Displays >55-fold selectivity for Mer kinase over other TAM receptor tyrosine kinase family members (IC50 values are 4.3 nM, 0.25 μM and 0.36 μM for Mer, Tyro3 and Alk, respectively). Inhibits Mer phosphorylation in vitro. Also inhibits platelet aggregation in response to Type I collagen.
Compound Libraries for UNC 2881
Technical Data for UNC 2881
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for UNC 2881
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for UNC 2881
The following data is based on the product molecular weight 463.58. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.31 mL||21.57 mL||43.14 mL|
|2.5 mM||0.86 mL||4.31 mL||8.63 mL|
|5 mM||0.43 mL||2.16 mL||4.31 mL|
|25 mM||0.09 mL||0.43 mL||0.86 mL|
References for UNC 2881
References are publications that support the biological activity of the product.
Zhang et al (2013) Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J.Med.Chem. 56 9693 PMID: 24219778
If you know of a relevant reference for UNC 2881, please let us know.
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Keywords: UNC 2881, UNC 2881 supplier, UNC2881, Mer, kinase, inhibitors, inhibts, TAM, receptor, tyrosine, kinases, platelet, aggregation, Other, RTKs, 6537, Tocris Bioscience
Citations for UNC 2881
Citations are publications that use Tocris products.
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