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Potent Mer kinase inhibitor. Displays >55-fold selectivity for Mer kinase over other TAM receptor tyrosine kinase family members (IC50 values are 4.3 nM, 0.25 μM and 0.36 μM for Mer, Tyro3 and Alk, respectively). Inhibits Mer phosphorylation in vitro. Also inhibits platelet aggregation in response to Type I collagen.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 463.58. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.31 mL||21.57 mL||43.14 mL|
|2.5 mM||0.86 mL||4.31 mL||8.63 mL|
|5 mM||0.43 mL||2.16 mL||4.31 mL|
|25 mM||0.09 mL||0.43 mL||0.86 mL|
References are publications that support the biological activity of the product.
Zhang et al (2013) Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J.Med.Chem. 56 9693 PMID: 24219778
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Keywords: UNC 2881, UNC 2881 supplier, UNC2881, Mer, kinase, inhibitors, inhibts, TAM, receptor, tyrosine, kinases, platelet, aggregation, Other, RTKs, 6537, Tocris Bioscience
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