UK 5099

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Cat.No. 4186 - UK 5099 | C18H12N2O2 | CAS No. 56396-35-1
Description: MCT inhibitor; also inhibits of pyruvate transport
Chemical Name: 2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Inhibitor of plasma membrane monocarboxylate transporters (MCTs) and the mitochondrial pyruvate carrier (MPC).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

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Technical Data

M. Wt 288.3
Formula C18H12N2O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 56396-35-1
PubChem ID 6438504
InChI Key BIZNHCWFGNKBBZ-JLHYYAGUSA-N
Smiles O=C(/C(C#N)=C/C2=CN(C3=CC=CC=C3)C1=CC=CC=C12)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.83 100

Preparing Stock Solutions

The following data is based on the product molecular weight 288.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.47 mL 17.34 mL 34.69 mL
5 mM 0.69 mL 3.47 mL 6.94 mL
10 mM 0.35 mL 1.73 mL 3.47 mL
50 mM 0.07 mL 0.35 mL 0.69 mL

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References

References are publications that support the biological activity of the product.

Wiemer et al (1995) The inhibition of pyruvate transport across the plasma membrane of the bloodstream form of Trypanosoma brucei and its metabolic implications. Biochem.J. 312 479 PMID: 8526859

Hildyard et al (2003) Identification of the mitochondrial pyruvate carrier in Saccharomyces cerevisiae. Biochem.J. 374 607 PMID: 12887330

Hinoi et al (2006) A molecular mechanism of pyruvate protection against cytotoxicity of reactive oxygen species in osteoblasts. Mol.Pharmacol. 70 925 PMID: 16766717


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Keywords: UK 5099, UK 5099 supplier, UK5099, inhibitor, transporters, mitochondrial, pyruvate, transport, inhibitors, MPT, inhibits, monocarboxylate, transporter, MCT, Monocarboxylate, Transporters, 4186, Tocris Bioscience

1 Citation for UK 5099

Citations are publications that use Tocris products. Selected citations for UK 5099 include:

Kaji et al (2015) SCFA transport in rat duodenum. Nat Chem Biol 308 G188 PMID: 25394661


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