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Inhibitor of plasma membrane monocarboxylate transporters (MCTs) and the mitochondrial pyruvate carrier (MPC).
Sold for research purposes under agreement from Pfizer Inc.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 288.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.47 mL||17.34 mL||34.69 mL|
|5 mM||0.69 mL||3.47 mL||6.94 mL|
|10 mM||0.35 mL||1.73 mL||3.47 mL|
|50 mM||0.07 mL||0.35 mL||0.69 mL|
References are publications that support the biological activity of the product.
Wiemer et al (1995) The inhibition of pyruvate transport across the plasma membrane of the bloodstream form of Trypanosoma brucei and its metabolic implications. Biochem.J. 312 479 PMID: 8526859
Hildyard et al (2003) Identification of the mitochondrial pyruvate carrier in Saccharomyces cerevisiae. Biochem.J. 374 607 PMID: 12887330
Hinoi et al (2006) A molecular mechanism of pyruvate protection against cytotoxicity of reactive oxygen species in osteoblasts. Mol.Pharmacol. 70 925 PMID: 16766717
If you know of a relevant reference for UK 5099, please let us know.
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Keywords: UK 5099, UK 5099 supplier, UK5099, inhibitor, transporters, mitochondrial, pyruvate, transport, inhibitors, MPT, inhibits, monocarboxylate, transporter, MCT, Monocarboxylate, Transporters, 4186, Tocris Bioscience
3 Citations for UK 5099
Citations are publications that use Tocris products. Selected citations for UK 5099 include:
Tompkins et al (2019) Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis. Cell Rep 28 2608 PMID: 31484072
Kaji et al (2015) SCFA transport in rat duodenum. Nat Chem Biol 308 G188 PMID: 25394661
Rauckhorst et al (2017) The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity. Mol Metab 6 1468 PMID: 29107293
Do you know of a great paper that uses UK 5099 from Tocris? Please let us know.
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Literature in this Area
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