UK 5099

Pricing Availability   Qty
Description: MCT inhibitor; also inhibits mitochondrial pyruvate carrier
Chemical Name: 2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid
Purity: ≥99% (HPLC)
Citations (3)
Literature (1)

Biological Activity for UK 5099

UK 5099 is an inhibitor of plasma membrane monocarboxylate transporters (MCTs) and the mitochondrial pyruvate carrier (MPC).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for UK 5099

UK 5099 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for UK 5099

M. Wt 288.3
Formula C18H12N2O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 56396-35-1
PubChem ID 6438504
Smiles O=C(/C(C#N)=C/C2=CN(C3=CC=CC=C3)C1=CC=CC=C12)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for UK 5099

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 28.83 100

Preparing Stock Solutions for UK 5099

The following data is based on the product molecular weight 288.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.47 mL 17.34 mL 34.69 mL
5 mM 0.69 mL 3.47 mL 6.94 mL
10 mM 0.35 mL 1.73 mL 3.47 mL
50 mM 0.07 mL 0.35 mL 0.69 mL

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References for UK 5099

References are publications that support the biological activity of the product.

Wiemer et al (1995) The inhibition of pyruvate transport across the plasma membrane of the bloodstream form of Trypanosoma brucei and its metabolic implications. Biochem.J. 312 479 PMID: 8526859

Hildyard et al (2003) Identification of the mitochondrial pyruvate carrier in Saccharomyces cerevisiae. Biochem.J. 374 607 PMID: 12887330

Hinoi et al (2006) A molecular mechanism of pyruvate protection against cytotoxicity of reactive oxygen species in osteoblasts. Mol.Pharmacol. 70 925 PMID: 16766717

If you know of a relevant reference for UK 5099, please let us know.

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Keywords: UK 5099, UK 5099 supplier, UK5099, inhibitor, transporters, mitochondrial, pyruvate, transport, inhibitors, MPT, inhibits, monocarboxylate, transporter, MCT, Monocarboxylate, Transporters, 4186, Tocris Bioscience

3 Citations for UK 5099

Citations are publications that use Tocris products. Selected citations for UK 5099 include:

Rauckhorst et al (2017) The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity. Mol Metab 6 1468 PMID: 29107293

Tompkins et al (2019) Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis. Cell Rep 28 2608 PMID: 31484072

Kaji et al (2015) SCFA transport in rat duodenum. Nat Chem Biol 308 G188 PMID: 25394661

Do you know of a great paper that uses UK 5099 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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