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Urotensin-II (UT) receptor ligand; behaves as a silent antagonist in most in vitro assays and in vivo, but does retain small residual agonist activity under certain conditions in some assays. Competitively antagonizes U-II induced contractions in the rat aorta (pIC50 = 7.46) and prevents plasma extravasation elicited by U-II in mice in vivo.
(Modifications: X-2 = Pen, Trp-4 = D-Trp, X-5 = Dab, Disulfide bridge between 2 - 7)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble in water|
References are publications that support the biological activity of the product.
Camarda et al (2006) In vitro and in vivo pharmacological characterization of the novel UT receptor ligand [Pen5,DTrp7,Dab8]urotensin II(4-11) (UFP-803). Br.J.Pharmacol. 147 92 PMID: 16273120
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Keywords: UFP 803, UFP 803 supplier, Urotensin, II, UT, antagonists, Receptors, Urotensin-II, UFP803, 2529, Tocris Bioscience
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