UFP 803

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Cat.No. 2529 - UFP 803 | Asp-Pen-Phe-D-Trp-Dab-Tyr-Cys-Val (Disulfide bridge: 2 - 7) | CAS No. 879497-82-2
Description: Urotensin-II (UT) antagonist
Datasheet
Citations
Literature

Biological Activity

Urotensin-II (UT) receptor ligand; behaves as a silent antagonist in most in vitro assays and in vivo, but does retain small residual agonist activity under certain conditions in some assays. Competitively antagonizes U-II induced contractions in the rat aorta (pIC50 = 7.46) and prevents plasma extravasation elicited by U-II in mice in vivo.

Technical Data

M. Wt 1061.24
Formula C50H64N10O12S2
Sequence DXFWXYCV

(Modifications: X-2 = Pen, Trp-4 = D-Trp, X-5 = Dab, Disulfide bridge between 2 - 7)

Storage Desiccate at -20°C
CAS Number 879497-82-2
PubChem ID 90488769
InChI Key LRELVPJTCGYTSS-AAEZYUNISA-N
Smiles [H]N[C@@H](CC(O)=O)C(=O)NC1C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@H](CC2=CNC3=C2C=CC=C3)C(=O)NC(CCN)C(=O)N[C@@H](CC2=CC=C(O)C=C2)C(=O)N[C@@H](CSSC1(C)C)C(=O)N[C@@H](C(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1061.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.94 mL 4.71 mL 9.42 mL
5 mM 0.19 mL 0.94 mL 1.88 mL
10 mM 0.09 mL 0.47 mL 0.94 mL
50 mM 0.02 mL 0.09 mL 0.19 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Camarda et al (2006) In vitro and in vivo pharmacological characterization of the novel UT receptor ligand [Pen5,DTrp7,Dab8]urotensin II(4-11) (UFP-803). Br.J.Pharmacol. 147 92 PMID: 16273120


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Keywords: Urotensin II UT antagonists Receptors Urotensin-II UFP803 Urotensin-II Receptors

Citations for UFP 803

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Pathways for UFP 803

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