UC 112

Pricing Availability   Qty
Description: IAP and XIAP inhibitor; antitumor
Chemical Name: 5-[(Phenylmethoxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol
Purity: ≥98% (HPLC)
Citations (1)
Literature (1)
Pathways (1)

Biological Activity for UC 112

UC 112 is an iAP inhibitor (IC50 values from 0.7 - 3.4 μM); inhibits cell growth in multiple cancer cell lines and in a melanoma xenograft model in vivo. Also suppresses X-linked inhibitor of apoptosis protein (XIAP) and survivin levels. Inhibits the growth of P-glycoproteins and activates caspase-3/7 and caspase-9.

Technical Data for UC 112

M. Wt 348.44
Formula C22H24N2O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 383392-66-3
PubChem ID 3426979

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for UC 112

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 34.84 100

Preparing Stock Solutions for UC 112

The following data is based on the product molecular weight 348.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.87 mL 14.35 mL 28.7 mL
5 mM 0.57 mL 2.87 mL 5.74 mL
10 mM 0.29 mL 1.43 mL 2.87 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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References for UC 112

References are publications that support the biological activity of the product.

Wang Discovery of novel second mitochondria-derived activator of caspase mimetics as selective inhibitor of apoptosis protein inhibitors. J.Pharmacol.Exp.Ther. 349 319 PMID: 24623800

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Keywords: UC 112, UC 112 supplier, UC112, inhibitors, inhibits, apoptosis, proteins, antitumor, multidrug, resistant, caspase, Inhibitor, of, Apoptosis, (IAP), 5251, Tocris Bioscience

1 Citation for UC 112

Citations are publications that use Tocris products. Selected citations for UC 112 include:

Schwalm et al (2022) A toolbox for the generation of chemical probes for baculovirus IAP repeat containing proteins Front.Cell.Dev.Biol. 10 886537 PMID: 35721509

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for UC 112

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.