U 83836E

Discontinued Product

Unfortunately U 83836E (Cat. No. 2750) has been withdrawn from sale for commercial reasons.
Cat.No. 2750 - U 82836E | C30H44N6O2.2HCl | CAS No. 137018-55-4
Description: Antioxidant; inhibits lipid peroxidation
Alternative Names: PNU 83836E
Chemical Name: (2R)-2-[[4-(2,6-Di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl]methyl]-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-6-ol dihydrochloride
Purity: ≥98% (HPLC)

Biological Activity

Free radical scavenger and antioxidant; second generation lazaroid that inhibits iron-dependent lipid peroxidation (IC50 = 1.5 μM). Displays neuroprotective activity in a mouse head injury model (MHI) and causes a reduction in cyanide-induced cell death in rat cortical neurons.

Technical Data

M. Wt 593.63
Formula C30H44N6O2.2HCl
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 137018-55-4
Smiles OC1=C(C)C(C)=C(O[C@](CN3CCN(C4=CC(N6CCCC6)=NC(N5CCCC5)=N4)CC3)(C)CC2)C2=C1C.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 593.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.68 mL 8.42 mL 16.85 mL
5 mM 0.34 mL 1.68 mL 3.37 mL
10 mM 0.17 mL 0.84 mL 1.68 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

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Product Datasheets

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References are publications that support the products' biological activity.

Jacobsen et al (1992) 2-(aminomethyl)chromans that inhibit iron-dependent lipid peroxidation and protect against central nervous system trauma and ischemia. J.Med.Chem. 35 4464 PMID: 1447746

Altavilla et al (1998) Inhibition of tumour necrosis factor and reversal of endotoxin-induced shock by U-83836E, a 'second generation' lazaroid in rats. Br.J.Pharmacol. 124 1293 PMID: 9720803

Vignes and Hugon (2006) In vitro efficacy of three lazaroids in a model of acute chemical neuronal hypoxia. Neurosci.Lett. 407 171 PMID: 16973271

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