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Free radical scavenger and antioxidant; second generation lazaroid that inhibits iron-dependent lipid peroxidation (IC50 = 1.5 μM). Displays neuroprotective activity in a mouse head injury model (MHI) and causes a reduction in cyanide-induced cell death in rat cortical neurons.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Jacobsen et al (1992) 2-(aminomethyl)chromans that inhibit iron-dependent lipid peroxidation and protect against central nervous system trauma and ischemia. J.Med.Chem. 35 4464 PMID: 1447746
Altavilla et al (1998) Inhibition of tumour necrosis factor and reversal of endotoxin-induced shock by U-83836E, a 'second generation' lazaroid in rats. Br.J.Pharmacol. 124 1293 PMID: 9720803
Vignes and Hugon (2006) In vitro efficacy of three lazaroids in a model of acute chemical neuronal hypoxia. Neurosci.Lett. 407 171 PMID: 16973271
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Keywords: U 82836E, U 82836E supplier, Antioxidant, inhibits, inhibitors, lipid, peroxidation, U82836E, PNU83836E, PNU, 83836E, Antioxidants, 2750, Tocris Bioscience
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