U 104

Pricing Availability Delivery Time Qty
Cat.No. 4540 - U 104 | C13H12FN3O3S | CAS No. 178606-66-1
Description: Potent carbonic anhydrase (CA) IX and XII inhibitor
Chemical Name: 4-[[[(4-Fluorophenyl)amino]carbonyl]amino]-benzesulfonamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent carbonic anhydrase (CA) inhibitor (Ki values are 4.5, 45.1, 5080 and 9640 nM for CA XII, CA IX, CA I and CA II respectively in MDA-MB-231 cells). Inhibits tumor metastasis in the rat 4T1 metastasis model.

Compound Libraries

U 104 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 309.32
Formula C13H12FN3O3S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 178606-66-1
PubChem ID 310360
InChI Key YJQZNWPYLCNRLP-UHFFFAOYSA-N
Smiles FC1=CC=C(NC(NC2=CC=C(S(=O)(N)=O)C=C2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.93 100

Preparing Stock Solutions

The following data is based on the product molecular weight 309.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.23 mL 16.16 mL 32.33 mL
5 mM 0.65 mL 3.23 mL 6.47 mL
10 mM 0.32 mL 1.62 mL 3.23 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Lou et al (2011) Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. Cancer Res. 71 3364 PMID: 21415165


If you know of a relevant reference for U 104, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Carbonic Anhydrase Inhibitors

Keywords: U 104, U 104 supplier, U104, supplier, potent, carbonic, anhydrase, XI, XII, 9, 12, CA, inhibitors, inhibits, metastatic, metastasis, hypoxic, hypoxia, Carbonic, anhydrases, 4540, Tocris Bioscience

Citations for U 104

Citations are publications that use Tocris products.

Currently there are no citations for U 104. Do you know of a great paper that uses U 104 from Tocris? Please let us know.

Reviews for U 104

There are currently no reviews for this product. Be the first to review U 104 and earn rewards!

Have you used U 104?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis