Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewU 104
Description: Potent carbonic anhydrase (CA) IX and XII inhibitor
Chemical Name: 4-[[[(4-Fluorophenyl)amino]carbonyl]amino]-benzesulfonamide
Purity: ≥99% (HPLC)
Biological Activity for U 104
U 104 is a potent carbonic anhydrase (CA) inhibitor (Ki values are 4.5, 45.1, 5080 and 9640 nM for CA XII, CA IX, CA I and CA II respectively in MDA-MB-231 cells). Inhibits tumor metastasis in the rat 4T1 metastasis model.
Compound Libraries for U 104
U 104 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for U 104
| M. Wt | 309.32 |
| Formula | C13H12FN3O3S |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 178606-66-1 |
| PubChem ID | 310360 |
| InChI Key | YJQZNWPYLCNRLP-UHFFFAOYSA-N |
| Smiles | FC1=CC=C(NC(NC2=CC=C(S(=O)(N)=O)C=C2)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for U 104
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.93 | 100 |
Preparing Stock Solutions for U 104
The following data is based on the product molecular weight 309.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.23 mL | 16.16 mL | 32.33 mL |
| 5 mM | 0.65 mL | 3.23 mL | 6.47 mL |
| 10 mM | 0.32 mL | 1.62 mL | 3.23 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.65 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for U 104
References for U 104
References are publications that support the biological activity of the product.
Lou et al (2011) Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. Cancer Res. 71 3364 PMID: 21415165
If you know of a relevant reference for U 104, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: U 104, U 104 supplier, U104, supplier, potent, carbonic, anhydrase, XI, XII, 9, 12, CA, inhibitors, inhibits, metastatic, metastasis, hypoxic, hypoxia, Carbonic, anhydrases, 4540, Tocris Bioscience
Citations for U 104
Citations are publications that use Tocris products.
Currently there are no citations for U 104. Do you know of a great paper that uses U 104 from Tocris? Please let us know.
Reviews for U 104
There are currently no reviews for this product. Be the first to review U 104 and earn rewards!
Have you used U 104?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis