U 104

Pricing Availability   Qty
Description: Potent carbonic anhydrase (CA) IX and XII inhibitor
Chemical Name: 4-[[[(4-Fluorophenyl)amino]carbonyl]amino]-benzesulfonamide
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity for U 104

U 104 is a potent carbonic anhydrase (CA) inhibitor (Ki values are 4.5, 45.1, 5080 and 9640 nM for CA XII, CA IX, CA I and CA II respectively in MDA-MB-231 cells). Inhibits tumor metastasis in the rat 4T1 metastasis model.

Compound Libraries for U 104

U 104 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for U 104

M. Wt 309.32
Formula C13H12FN3O3S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 178606-66-1
PubChem ID 310360
Smiles FC1=CC=C(NC(NC2=CC=C(S(=O)(N)=O)C=C2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for U 104

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 30.93 100

Preparing Stock Solutions for U 104

The following data is based on the product molecular weight 309.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.23 mL 16.16 mL 32.33 mL
5 mM 0.65 mL 3.23 mL 6.47 mL
10 mM 0.32 mL 1.62 mL 3.23 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

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References for U 104

References are publications that support the biological activity of the product.

Lou et al (2011) Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. Cancer Res. 71 3364 PMID: 21415165

If you know of a relevant reference for U 104, please let us know.

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Citations for U 104

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Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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